Statistical optimization of high temperature/pressure and ultra-wave assisted lysis of Urechis unicinctus for the isolation of active peptide which enhance the erectile function in vitro

Ryu, BoMi, Kim, MinJeong, Himaya, S. W. A., Kang, Kyong-Hwa and Kim, Se-Kwon (2014) Statistical optimization of high temperature/pressure and ultra-wave assisted lysis of Urechis unicinctus for the isolation of active peptide which enhance the erectile function in vitro. Process Biochemistry, 49 1: 148-153. doi:10.1016/j.procbio.2013.09.019


Author Ryu, BoMi
Kim, MinJeong
Himaya, S. W. A.
Kang, Kyong-Hwa
Kim, Se-Kwon
Title Statistical optimization of high temperature/pressure and ultra-wave assisted lysis of Urechis unicinctus for the isolation of active peptide which enhance the erectile function in vitro
Formatted title
Statistical optimization of high temperature/pressure and ultra-wave assisted lysis of Urechis unicinctus for the isolation of active peptide which enhance the erectile function in vitro
Journal name Process Biochemistry   Check publisher's open access policy
ISSN 1359-5113
1873-3298
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.procbio.2013.09.019
Open Access Status Not yet assessed
Volume 49
Issue 1
Start page 148
End page 153
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Subject 1502 Bioengineering
1303 Biochemistry
2402 Applied Microbiology and Biotechnology
Abstract High temperature/pressure and ultra-waves could be applied to lyse substances into small units to facilitate absorbance in the human intestine. Hydrolysed substances are widely reported for their specific bioactivities. However, the establishment of optimal condition for the lysis process is crucial for their prospective commercial applications. Consumption of marine echiuran worm, Urechis unicinctus (U. unicinctus) is generally known to enhance erectile function. However, there are less scientific reports on the same. In this study efforts were taken to optimize the high temperature/pressure and ultra-wave assisted lysis conditions to isolate active peptide with erectile function inducing activity. According to the results the isolated peptide (DDL, 361.15 Da) showed a high potential to enhance erectile function in vitro. The optimal lysis conditions for the isolation were analyzed using response surface methodology (RSM).
Keyword High temperature/pressure
Response surface methodology (RSM)
Ultra-wave, Erectile function
Urechis unicinctus (U. unicinctus)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 27 September 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Pharmacy Publications
 
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