The demographic profile of young patients (<45 years-old) with acute coronary syndromes in Queensland

Chen, Tony Shang-Chuan, Incani, Alexander, Butler, Tom C., Poon, Karl, Fu, Jinlin, Savage, Michael, Dahl, Margaret, Callow, Donna E., Colburn, Daniel, Hammett, Chris and Walters, Darren L. (2014) The demographic profile of young patients (<45 years-old) with acute coronary syndromes in Queensland. Heart Lung and Circulation, 23 1: 49-55. doi:10.1016/j.hlc.2013.05.648

Author Chen, Tony Shang-Chuan
Incani, Alexander
Butler, Tom C.
Poon, Karl
Fu, Jinlin
Savage, Michael
Dahl, Margaret
Callow, Donna E.
Colburn, Daniel
Hammett, Chris
Walters, Darren L.
Title The demographic profile of young patients (<45 years-old) with acute coronary syndromes in Queensland
Journal name Heart Lung and Circulation   Check publisher's open access policy
ISSN 1443-9506
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.hlc.2013.05.648
Open Access Status Not Open Access
Volume 23
Issue 1
Start page 49
End page 55
Total pages 7
Place of publication Chatswood, NSW, Australia
Publisher Elsevier
Language eng
Formatted abstract
Background: There is little data regarding the demographic profile of young (<45 years) Australian acute coronary syndrome patients. The aim of this study was to compare baseline characteristics, risk factor profile and outcomes of young patients compared with their older counterparts referred to two metropolitan Queensland hospitals.

Methods: Over a four-year period, data on acute coronary syndrome patients referred to The Prince Charles and Royal Brisbane Hospitals were retrospectively analysed. Three major groups were identified: <45 years, 45-60 years and those >60 years. Age, sex, body mass index, risk factor profile, degree of coronary disease, left ventricular dysfunction, mode of presentation, initial pharmacological therapy and mortality data were compared between the three groups.

Results: 4549 patients were analysed of whom, 277 were less than 45 years old. Younger patients tended to be male, more overweight and present more commonly with ST segment elevation myocardial infarction compared to their older counterparts. Smoking, family history and dyslipidaemia tended to occur more frequently in younger patients as compared to those >45 years. Those patients >45 years tended to present with non-ST segment elevation myocardial infarction and have a higher degree of ischaemic burden and left ventricular dysfunction. No patients <45 years died in their index admission at 30 days or at one year.

Conclusions: Although young patients <45 years make up the minority (6.1%) of patients presenting with acute coronary syndrome and generally have a favourable prognosis, this paper highlights the need for aggressive risk factor modification, with particular attention to smoking and dyslipidaemia, before the onset of overt clinical disease. 
Keyword Acute coronary syndrome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
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