L1 retrotransposons, cancer stem cells and oncogenesis

Carreira, Patricia E., Richardson, Sandra R. and Faulkner, Geoffrey J. (2014) L1 retrotransposons, cancer stem cells and oncogenesis. FEBS Journal, 281 1: 63-73. doi:10.1111/febs.12601

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Author Carreira, Patricia E.
Richardson, Sandra R.
Faulkner, Geoffrey J.
Title L1 retrotransposons, cancer stem cells and oncogenesis
Journal name FEBS Journal   Check publisher's open access policy
ISSN 1742-464X
Publication date 2014-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/febs.12601
Open Access Status Not yet assessed
Volume 281
Issue 1
Start page 63
End page 73
Total pages 11
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Abstract Retrotransposons have played a central role in human genome evolution. The accumulation of heritable L1, Alu and SVA retrotransposon insertions continues to generate structural variation within and between populations, and can result in spontaneous genetic disease. Recent works have reported somatic L1 retrotransposition in tumours, which in some cases may contribute to oncogenesis. Intriguingly, L1 mobilization appears to occur almost exclusively in cancers of epithelial cell origin. In this review, we discuss how L1 retrotransposition could potentially trigger neoplastic transformation, based on the established correlation between L1 activity and cellular plasticity, and the proven capacity of L1-mediated insertional mutagenesis to decisively alter gene expression and functional output.
Keyword Alu
Cancer genomics
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID GNT1045237
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2014 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 38 times in Scopus Article | Citations
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