Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers

Wunnapuk, Klintean, Gobe, Glenda, Endre, Zoltan, Peake, Philip, Grice, Jeffrey E., Roberts, Michael S., Buckley, Nicholas A. and Liu, Xin (2014) Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers. Toxicology Letters, 225 1: 192-200. doi:10.1016/j.toxlet.2013.12.009


Author Wunnapuk, Klintean
Gobe, Glenda
Endre, Zoltan
Peake, Philip
Grice, Jeffrey E.
Roberts, Michael S.
Buckley, Nicholas A.
Liu, Xin
Title Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers
Journal name Toxicology Letters   Check publisher's open access policy
ISSN 0378-4274
1879-3169
Publication date 2014-02-10
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.toxlet.2013.12.009
Open Access Status Not yet assessed
Volume 225
Issue 1
Start page 192
End page 200
Total pages 9
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Language eng
Subject 3005 Toxicology
Abstract Accidental or intentional ingestion of glyphosate surfactant-based herbicides, like Roundup®, leads to nephrotoxicity as well as death. In this study, a panel of kidney injury biomarkers was evaluated in terms of suitability to detect acute kidney injury and dysfunction. The Roundup® intoxication model involved oral administration of glyphosate to rats at dose levels of 250, 500, 1200 and 2500mg/kg. Urinary and plasma biomarker patterns were investigated at 8, 24 and 48h after dosing. Biomarkers were quantified by absolute concentration; by normalising to urine creatinine; and by calculating the excretion rate. The diagnostic performances of each method in predicting of acute kidney injury were compared. By Receiver Operating Characteristic (ROC) analysis of the selected biomarkers, only urinary kidney injury molecule-1 (KIM-1) best predicted histological changes at 8h (best cut-off point>0.00029μg/ml). Plasma creatinine performed better than other biomarkers at 24h (best cut-off point>0.21mg/dl). Urinary KIM-1 was the best early biomarker of kidney injury in this glyphosate-induced nephrotoxicity model.
Keyword Acute kidney injury
Creatinine
Cystatin-C
Glyphosate
Kidney injury molecule-1
Roundup
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 1011772
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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