A role for the neurexin-neuroligin complex in Alzheimer's disease

Sindi, Ikhlas A., Tannenberg, Rudolph K. and Dodd, Peter R. (2014) A role for the neurexin-neuroligin complex in Alzheimer's disease. Neurobiology of Aging, 35 4: 746-756. doi:10.1016/j.neurobiolaging.2013.09.032

Author Sindi, Ikhlas A.
Tannenberg, Rudolph K.
Dodd, Peter R.
Title A role for the neurexin-neuroligin complex in Alzheimer's disease
Journal name Neurobiology of Aging   Check publisher's open access policy
ISSN 0197-4580
Publication date 2014-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.neurobiolaging.2013.09.032
Open Access Status Not yet assessed
Volume 35
Issue 4
Start page 746
End page 756
Total pages 11
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Subject 2728 Clinical Neurology
2800 Neuroscience
1302 Ageing
1309 Developmental Biology
2717 Geriatrics and Gerontology
Abstract Synaptic damage is a critical hallmark of Alzheimer's disease, and the best correlate with cognitive impairment ante mortem. Synapses, the loci of communication between neurons, are characterized by signature protein combinations arrayed at tightly apposed pre- and post-synaptic sites. The most widely studied trans-synaptic junctional complexes, which direct synaptogenesis and foster the maintenance and stability of the mature terminal, are conjunctions of presynaptic neurexins and postsynaptic neuroligins. Fluctuations in the levels of neuroligins and neurexins can sway the balance between excitatory and inhibitory neurotransmission in the brain, and could lead to damage of synapses and dendrites. This review summarizes current understanding of the roles of neurexins and neuroligins proteolytic processing in synaptic plasticity in the human brain, and outlines their possible roles in β-amyloid metabolism and function, which are central pathogenic events in Alzheimer's disease progression.
Keyword Acetylcholinesterase (AChE)
Alternative splicing
Cell adhesion molecules
Excitatory synapses
Inhibitory synapses
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 6 November 2013.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
School of Medicine Publications
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