MrIC, a novel alpha-conotoxin agonist in the presence of PNU at endogenous alpha-7 nicotinic acetylcholine receptors

Jin, Ai-Hua, Vetter, Irina, Dutertre, Sébastien, Abraham, Nikita, Emidio, Nayara B., Inserra, Marco, Murali, Swetha S., Christie, MacDonald J., Alewood, Paul F. and Lewis, Richard J. (2014) MrIC, a novel alpha-conotoxin agonist in the presence of PNU at endogenous alpha-7 nicotinic acetylcholine receptors. Biochemistry, 53 1: 1-3. doi:10.1021/bi400882s


Author Jin, Ai-Hua
Vetter, Irina
Dutertre, Sébastien
Abraham, Nikita
Emidio, Nayara B.
Inserra, Marco
Murali, Swetha S.
Christie, MacDonald J.
Alewood, Paul F.
Lewis, Richard J.
Title MrIC, a novel alpha-conotoxin agonist in the presence of PNU at endogenous alpha-7 nicotinic acetylcholine receptors
Formatted title
MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors
Journal name Biochemistry   Check publisher's open access policy
ISSN 0006-2960
1520-4995
Publication date 2014-01-14
Year available 2013
Sub-type Article (original research)
DOI 10.1021/bi400882s
Volume 53
Issue 1
Start page 1
End page 3
Total pages 3
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Formatted abstract
α-Conotoxins are competitive antagonists of nicotinic acetylcholine receptors (nAChRs). Their high selectivity and affinity for the various subtypes of nAChRs have led to significant advances in our understanding of the structure and function of these key ion channels. Here we report the discovery of a novel 4/7 α-conotoxin, MrIC from the venom duct of Conus marmoreus, which acts as an agonist at the endogenous human α7 nAChR in SH-SY5Y cells pretreated with PNU120596 (PNU). This unique agonist activity of MrIC at α7 nAChRs may guide the development of novel α7 nAChR modulators.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Publication Date (Web): December 18, 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 27 Jan 2014, 06:01:55 EST by Dr Irina Vetter on behalf of Institute for Molecular Bioscience