Self-assembled magnetic luminescent hybrid micelles containing rare earth Eu for dual-modality MR and optical imaging

Yan, Kai, Li, Huan, Wang, Xin, Yi, Changfeng, Zhang, Quanyuan, Xu, Zushun, Xu, Haibo and Whittaker, Andrew K. (2014) Self-assembled magnetic luminescent hybrid micelles containing rare earth Eu for dual-modality MR and optical imaging. Journal of Materials Chemistry B, 2 5: 546-555. doi:10.1039/c3tb21381a


Author Yan, Kai
Li, Huan
Wang, Xin
Yi, Changfeng
Zhang, Quanyuan
Xu, Zushun
Xu, Haibo
Whittaker, Andrew K.
Title Self-assembled magnetic luminescent hybrid micelles containing rare earth Eu for dual-modality MR and optical imaging
Journal name Journal of Materials Chemistry B   Check publisher's open access policy
ISSN 2050-750X
2050-7518
Publication date 2014-02-07
Year available 2013
Sub-type Article (original research)
DOI 10.1039/c3tb21381a
Open Access Status Not Open Access
Volume 2
Issue 5
Start page 546
End page 555
Total pages 10
Place of publication Cambridge,United Kingdom
Publisher R S C Publications
Language eng
Subject 1600 Chemistry
2204 Religion and Religious Studies
2700 Medicine
2500 Materials Science
Abstract In this study, we report new water-soluble multifunctional nanomaterials based on amphiphilic poly(HFMA-co-Eu(AA)3Phen)-g-PEG copolymers and oleic acid modified Fe3O4 nanoparticles. The nanoparticles can self-assemble to form magnetic and luminescent hybrid micelles and show a spherical morphology, paramagnetic properties with a maximum saturation magnetization of 7.05 emu g-1, and a high transverse relaxivity of 340 mM-1 s-1. According to in vivo magnetic resonance imaging (MRI) experiments, excellent contrast of the liver and spleen was achieved after injection of the hybrid micelles. Fluorescence spectra show characteristic emission peaks from the rare earth Eu at 616 nm and vivid red fluorescence can be observed by 2-photon confocal laser scanning microscopy (CLSM). In vivo optical imaging demonstrates the unique fluorescent characteristics of the magnetic and luminescent hybrid micelles in the liver and spleen and the excellent multifunctional properties suggest the possibility of clinical use as nanocarriers in magnetic resonance imaging and optical imaging.
Keyword Materials Science, Biomaterials
Materials Science
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 51273058
2011CB933103
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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