Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment

Panizza, Benedict, Warren, Timothy A., Solares, C. Arturo, Boyle, Glen M., Lambie, Duncan and Brown, Ian (2013) Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment. Head and Neck, 36 11: 1611-1618. doi:10.1002/hed.23509


Author Panizza, Benedict
Warren, Timothy A.
Solares, C. Arturo
Boyle, Glen M.
Lambie, Duncan
Brown, Ian
Title Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment
Journal name Head and Neck   Check publisher's open access policy
ISSN 1043-3074
1097-0347
Publication date 2013-12-18
Year available 2013
Sub-type Article (original research)
DOI 10.1002/hed.23509
Open Access Status Not Open Access
Volume 36
Issue 11
Start page 1611
End page 1618
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Background: Nonmelanoma skin cancer (NMSC) with perineural invasion (PNI) is most commonly seen in cutaneous squamous cell carcinoma of the head and neck (SCCHN). The cranial nerves are a conduit for skin cancer to reach the brainstem.

Methods: The histopathological features of 51 tissue specimens from 49 patients with cutaneous SCCHN and clinical PNI were assessed with consecutive transverse and longitudinal sections.

Results: No skip lesions were identified. Tumor spread was contiguous in all specimens. No tumor spread into the perineural space from surrounding or adjacent tumor was seen. Proximal large cranial nerves showed epineural involvement in 3.9% in areas with large tumor bulk, extensive PNI, and intraneural invasion.

Conclusion: Perineural tumor spread in cutaneous SCCHN was contiguous and no skip lesions were evident in nerve specimens assessed in this series. Spread beyond cranial nerve perineurium was uncommon, reflecting its multilayer barrier function at this level. These findings may have treatment implications.
Keyword Skin cancer
Head and neck neoplasms
Peripheral nerve neoplastic infiltration
Perineurium
Squamous cell carcinoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 18 December 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 25 Jan 2014, 22:52:00 EST by Dr Benedict Panizza on behalf of Surgery - Princess Alexandra Hospital