Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Freathy, Rachel M., Mook-Kanamor, Dennis O., Sovio, Ulla, Prokopenko, Inga, Timpson, Nicholas J., Berry, Diane J., Warrington, Nicole M., Widen, Elisabeth, Hottenga, Jouke Jan, Kaakinen, Marika, Lange, Leslie A., Bradfield, Jonathan P., Kerkhof, Marjan, Marsh, Julie A., Magi, Reedik, Chen, Chih-Mei, Lyon, Helen N., Kirin, Mirna, Adair, Linda S., Aulchenko, Yurii S., Bennett, Amanda J., Borja, Judith B., Bouatia-Naji, Nabila, Charoen, Pimphen, Coin, Lachlan ..J. M., Cousminer, Diana L., De Geus, Eco J. C., Deloukas, Panos, Elliott, Paul, Evans, David M., Froguel, Philippe, Glaser, Beate, Groves, Christopher J., Hartikainen, Anna-Liisa, Hassanali, Neelam, Hirschhorn, Joel N., Hofman, Albert, Holly, Jeff M. P., Hypponen, Elina, Kanoni, Stavroula, Knight, Bridget A., Laitinen, Jaana, Lindgren, Cecilia M., McArdle, Wendy L., O'Reilly, Paul F., Pennell, Craig E., Postma, Dirkje. S., Pouta, Anneli, Ramasamy, Adaikalavan, Rayner, Nigel W., Ring, Susan M., Rivadeneira, Femando, Shields, Beverley M., Strachan, David P., Surakka, Ida, Taanila, Anja, Tiesler, Carta, Uitterlinden, Andre G., van Duijn, Cornelia M., Wijga, Alet H., Willemsen, Gonneke, Zhang, Haitao, Zhao, Jianhua, Wilson, James F., Steegers, Eric A. P., Hattersley, Andrew T., Eriksson, Johan G., Peltonen, Leena, Mohlke, Karen L., Grant, Struan F. A., Hakonarson, Hakon, Koppelman, George H., Dedoussis, George V., Heinrich, Joachim, Gillman, Matthew W., Palmer, Lyle J., Frayling, Timothy M., Boomsma, Dorret I., Smith, George Davey, Power, Chris, Jaddoe, Vincent W. V., Jarvelin, Marjo-Riitta and McCarthy, Mark I. (2010) Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42 5: 430-435. doi:10.1038/ng.567

Author Freathy, Rachel M.
Mook-Kanamor, Dennis O.
Sovio, Ulla
Prokopenko, Inga
Timpson, Nicholas J.
Berry, Diane J.
Warrington, Nicole M.
Widen, Elisabeth
Hottenga, Jouke Jan
Kaakinen, Marika
Lange, Leslie A.
Bradfield, Jonathan P.
Kerkhof, Marjan
Marsh, Julie A.
Magi, Reedik
Chen, Chih-Mei
Lyon, Helen N.
Kirin, Mirna
Adair, Linda S.
Aulchenko, Yurii S.
Bennett, Amanda J.
Borja, Judith B.
Bouatia-Naji, Nabila
Charoen, Pimphen
Coin, Lachlan ..J. M.
Cousminer, Diana L.
De Geus, Eco J. C.
Deloukas, Panos
Elliott, Paul
Evans, David M.
Froguel, Philippe
Glaser, Beate
Groves, Christopher J.
Hartikainen, Anna-Liisa
Hassanali, Neelam
Hirschhorn, Joel N.
Hofman, Albert
Holly, Jeff M. P.
Hypponen, Elina
Kanoni, Stavroula
Knight, Bridget A.
Laitinen, Jaana
Lindgren, Cecilia M.
McArdle, Wendy L.
O'Reilly, Paul F.
Pennell, Craig E.
Postma, Dirkje. S.
Pouta, Anneli
Ramasamy, Adaikalavan
Rayner, Nigel W.
Ring, Susan M.
Rivadeneira, Femando
Shields, Beverley M.
Strachan, David P.
Surakka, Ida
Taanila, Anja
Tiesler, Carta
Uitterlinden, Andre G.
van Duijn, Cornelia M.
Wijga, Alet H.
Willemsen, Gonneke
Zhang, Haitao
Zhao, Jianhua
Wilson, James F.
Steegers, Eric A. P.
Hattersley, Andrew T.
Eriksson, Johan G.
Peltonen, Leena
Mohlke, Karen L.
Grant, Struan F. A.
Hakonarson, Hakon
Koppelman, George H.
Dedoussis, George V.
Heinrich, Joachim
Gillman, Matthew W.
Palmer, Lyle J.
Frayling, Timothy M.
Boomsma, Dorret I.
Smith, George Davey
Power, Chris
Jaddoe, Vincent W. V.
Jarvelin, Marjo-Riitta
McCarthy, Mark I.
Title Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2010-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1038/ng.567
Open Access Status Not yet assessed
Volume 42
Issue 5
Start page 430
End page 435
Total pages 6
Place of publication New York, NY United States
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 × 10 35) and rs9883204 in ADCY5 (P = 7 × 10 15) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113g (95% CI 89-137g) lighter at birth than the 24% with zero or one alleles (P trend = 7 × 10 30). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy.
Keyword Genetics & Heredity
Genetics & Heredity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 104781
MOP 82893
FKZ: 01GI0826
SPI 56-464-14192
ZonMw 90700303
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Institute for Molecular Bioscience - Publications
UQ Diamantina Institute Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 128 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 129 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 25 Jan 2014, 05:08:04 EST by System User on behalf of Institute for Molecular Bioscience