Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

Meyre, David, Delplanque, Jerome, Chevre, Jean-Claude, Lecoeur, Cecile, Lobbens, Stephane, Gallina, Sophie, Durand, Emmanuelle, Vatin, Vincent, Degraeve, Franck, Proenca, Christine, Gaget, Stefan, Korner, Antje, Kovacs, Peter, Kiess, Wieland, Tichet, Jean, Marre, Michel, Hartikainen, Anna-Liisa, Horber, Fritz, Potoczna, Natascha, Hercberg, Serge, Levy-Marchal, Claire, Pattou, Francois, Heude, Barbara, Tauber, Maithe´, McCarthy, Mark I., Blakemore, Alexandra I. F., Montpetit, Alexandre, Polychronakos, Constantin, Weill, Jacques, Coin, Lachlan J. M., Asher, Julian, Elliott, Paul, Jarvelin, Marjo-Riitta, Visvikis-Siest, Sophie, Balkau, Beverley, Sladek, Rob, Balding, David, Walley, Andrew, Dina, Christian and Froguel, Philippe (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nature Genetics, 41 2: 157-159. doi:10.1038/ng.301


Author Meyre, David
Delplanque, Jerome
Chevre, Jean-Claude
Lecoeur, Cecile
Lobbens, Stephane
Gallina, Sophie
Durand, Emmanuelle
Vatin, Vincent
Degraeve, Franck
Proenca, Christine
Gaget, Stefan
Korner, Antje
Kovacs, Peter
Kiess, Wieland
Tichet, Jean
Marre, Michel
Hartikainen, Anna-Liisa
Horber, Fritz
Potoczna, Natascha
Hercberg, Serge
Levy-Marchal, Claire
Pattou, Francois
Heude, Barbara
Tauber, Maithe´
McCarthy, Mark I.
Blakemore, Alexandra I. F.
Montpetit, Alexandre
Polychronakos, Constantin
Weill, Jacques
Coin, Lachlan J. M.
Asher, Julian
Elliott, Paul
Jarvelin, Marjo-Riitta
Visvikis-Siest, Sophie
Balkau, Beverley
Sladek, Rob
Balding, David
Walley, Andrew
Dina, Christian
Froguel, Philippe
Title Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2009-01-01
Sub-type Article (original research)
DOI 10.1038/ng.301
Open Access Status Not Open Access
Volume 41
Issue 2
Start page 157
End page 159
Total pages 3
Place of publication New York, NY, United States
Publisher Nature Publishing
Language eng
Subject 1311 Genetics
Abstract We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 × 10-7), near MAF (encoding the transcription factor c-MAF, P = 3.8 × 10 -13) and near PTER (phosphotriesterase-related gene, P = 2.1 × 10-7).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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