Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction

Flavell, Charlotte R., Lambert, Elliot A., Winters, Boyer D. and Bredy, Timothy W. (2013) Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction. Frontiers in Behavioral Neuroscience, 7 DEC: 214.1-214.11. doi:10.3389/fnbeh.2013.00214

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Author Flavell, Charlotte R.
Lambert, Elliot A.
Winters, Boyer D.
Bredy, Timothy W.
Title Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction
Journal name Frontiers in Behavioral Neuroscience   Check publisher's open access policy
ISSN 1662-5153
Publication date 2013-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fnbeh.2013.00214
Open Access Status DOI
Volume 7
Issue DEC
Start page 214.1
End page 214.11
Total pages 11
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Abstract The extinction of learned associations has traditionally been considered to involve new learning, which competes with the original memory for control over behavior. However, a recent resurgence of interest in reactivation-dependent amnesia has revealed that the retrieval of fear-related memory (with what is essentially a brief extinction session) can result in its destabilization. This review discusses some of the cellular and molecular mechanisms that are involved in the destabilization of a memory following its reactivation and/or extinction, and investigates the evidence that extinction may involve both new learning as well as a partial destabilization-induced erasure of the original memory trace.
Keyword Extinction
Reconsolidation
Destabilization
Reactivation
Memory
Fear
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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