Spatial navigation in young versus older adults

Gazova, Ivana, Laczo, Jan, Rubinova, Eva, Mokrisova, Ivana, Hyncicova, Eva, Andel, Ross, Vyhnalek, Martin, Sheardova, Katerina, Coulson, Elizabeth J. and Hort, Jakub (2013) Spatial navigation in young versus older adults. Frontiers in Aging Neuroscience, 5 DEC: 94.1-94.8. doi:10.3389/fnagi.2013.00094

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Gazova, Ivana
Laczo, Jan
Rubinova, Eva
Mokrisova, Ivana
Hyncicova, Eva
Andel, Ross
Vyhnalek, Martin
Sheardova, Katerina
Coulson, Elizabeth J.
Hort, Jakub
Title Spatial navigation in young versus older adults
Journal name Frontiers in Aging Neuroscience   Check publisher's open access policy
ISSN 1663-4365
Publication date 2013-12-01
Sub-type Article (original research)
DOI 10.3389/fnagi.2013.00094
Open Access Status DOI
Volume 5
Issue DEC
Start page 94.1
End page 94.8
Total pages 8
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Formatted abstract
Older age is associated with changes in the brain, including the medial temporal lobe, which may result in mild spatial navigation deficits, especially in allocentric navigation. The aim of the study was to characterize the profile of real-space allocentric (world-centered, hippocampus-dependent) and egocentric (body-centered, parietal lobe dependent) navigation and learning in young vs. older adults, and to assess a possible influence of gender. We recruited healthy participants without cognitive deficits on standard neuropsychological testing, white matter lesions or pronounced hippocampal atrophy: 24 young participants (18–26 years old) and 44 older participants stratified as participants 60–70 years old (n = 24) and participants 71–84 years old (n = 20). All underwent spatial navigation testing in the real-space human analog of the Morris Water Maze, which has the advantage of assessing separately allocentric and egocentric navigation and learning. Of the eight consecutive trials, trials 2–8 were used to reduce bias by a rebound effect (more dramatic changes in performance between trials 1 and 2 relative to subsequent trials). The participants who were 71–84 years old (p < 0.001), but not those 60–70 years old, showed deficits in allocentric navigation compared to the young participants. There were no differences in egocentric navigation. All three groups showed spatial learning effect (p’ s ≤ 0.01). There were no gender differences in spatial navigation and learning. Linear regression limited to older participants showed linear (β = 0.30, p = 0.045) and quadratic (β = 0.30, p = 0.046) effect of age on allocentric navigation. There was no effect of age on egocentric navigation. These results demonstrate that navigation deficits in older age may be limited to allocentric navigation, whereas egocentric navigation and learning may remain preserved. This specific pattern of spatial navigation impairment may help differentiate normal aging from prodromal Alzheimer’s disease.
Keyword Spatial navigation
Allocentric navigation
Egocentric navigation
Spatial learning
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 19 Jan 2014, 10:02:48 EST by System User on behalf of Queensland Brain Institute