Synthesis and characterization of a novel POSS-PEG macromonomer and POSS-PEG-PLA hydrogels for periodontal applications

Wang, David K., Varanasi, Srinivas, Strounina, Ekaterina, Hill, David J. T., Symons, Anne L., Whittaker, Andrew K. and Rasoul, Firas (2014) Synthesis and characterization of a novel POSS-PEG macromonomer and POSS-PEG-PLA hydrogels for periodontal applications. Biomacromolecules, 15 2: 666-679. doi:10.1021/bm401728p


Author Wang, David K.
Varanasi, Srinivas
Strounina, Ekaterina
Hill, David J. T.
Symons, Anne L.
Whittaker, Andrew K.
Rasoul, Firas
Title Synthesis and characterization of a novel POSS-PEG macromonomer and POSS-PEG-PLA hydrogels for periodontal applications
Journal name Biomacromolecules   Check publisher's open access policy
ISSN 1525-7797
1526-4602
Publication date 2014-01-13
Year available 2014
Sub-type Article (original research)
DOI 10.1021/bm401728p
Volume 15
Issue 2
Start page 666
End page 679
Total pages 14
Place of publication Washington, United States
Publisher American Chemical Society
Language eng
Abstract A novel water-soluble macromonomer based on octavinyl silsesquioxane has been synthesized and contains vinyl-terminated PEG 400 in each of the eight arms to promote water solubility. The macromonomer was characterized by NMR and FTIR, and its aqueous solution properties examined. In water it exhibits an LCST with a cloud point at 23 °C for a 10 wt% aqueous solution. It is surface active with a CMC of 1.5 x 10-5 M in water and in 20:80 v/v acetone:water the CMC is 7.1 x 10-5 M, and TEM images showed spherical 22 nm aggregates in aqueous solution above the CMC. The macromonomer was copolymerized in a 20:80 v/v acetone:water mixture with a vinyl-terminated, triblock copolymer of lactide-PEG-lactide to form a library of crosslinked hydrogels that were designed for use as scaffolds for alveolar bone repair. The crosslinked copolymer networks were shown to contain a range of nm-µm sized pores and their swelling properties in water and PBS at pH 7.4 were examined. At pH 7.4 the hydrogel networks undergo a slow hydrolysis with the release of principally PEG and lactic acid fragments. The hydrogels were shown to be non-cytotoxic towards fibroblast cultures at pH 7.4, both initially (days 1-5) and after significant hydrolysis had taken place (days 23-28).
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 13 January 2014.

 
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Created: Thu, 16 Jan 2014, 20:03:41 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging