Assessing the bioavailability and bioaccessibility of metals and metalloids

Ng, Jack C., Juhasz, Albert, Smith, Euan and Naidu, Ravi (2013) Assessing the bioavailability and bioaccessibility of metals and metalloids. Environmental Science and Pollution Research, 22 12: 8802-8825. doi:10.1007/s11356-013-1820-9

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Author Ng, Jack C.
Juhasz, Albert
Smith, Euan
Naidu, Ravi
Title Assessing the bioavailability and bioaccessibility of metals and metalloids
Journal name Environmental Science and Pollution Research   Check publisher's open access policy
ISSN 0944-1344
1614-7499
Publication date 2013-06-14
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s11356-013-1820-9
Open Access Status Not yet assessed
Volume 22
Issue 12
Start page 8802
End page 8825
Total pages 24
Editor Céline Guéguen
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract Bioavailability (BA) determines the potential harm of a contaminant that exerts on the receptor. However, environmental guidelines for site contamination assessment are often set assuming the contaminant is 100 % bioavailable. This conservative approach to assessing site risk may result in the unnecessary and expensive remediation of a contaminated site. The National Environmental Protection Measures in Australia has undergone a statutory 5-year review that recommended that contaminant bioavailability and bioaccessibility (BAC) measures be adopted as part of the contaminated site risk assessment process by the National Environment Protection Council. We undertook a critical review of the current bioavailability and bioaccessibility approaches, methods and their respective limitations. The 'gold' standard to estimate the portion of a contaminant that reaches the system circulatory system (BA) of its receptor is to determine BA in an in vivo system. Various animal models have been utilised for this purpose. Because of animal ethics issues, and the expenses associated with performing in vivo studies, several in vitro methods have been developed to determine BAC as a surrogate model for the estimation of BA. However, few in vitro BAC studies have been calibrated against a reliable animal model, such as immature swine. In this review, we have identified suitable methods for assessing arsenic and lead BAC and proposed a decision tree for the determination of contaminant bioavailability and bioaccessibility for health risk assessment.
Formatted abstract
Bioavailability (BA) determines the potential harm of a contaminant that exerts on the receptor. However, environmental guidelines for site contamination assessment are often set assuming the contaminant is 100 % bioavailable. This conservative approach to assessing site risk may result in the unnecessary and expensive remediation of a contaminated site. The National Environmental Protection Measures in Australia has undergone a statutory 5-year review that recommended that contaminant bioavailability and bioaccessibility (BAC) measures be adopted as part of the contaminated site risk assessment process by the National Environment Protection Council. We undertook a critical review of the current bioavailability and bioaccessibility approaches, methods and their respective limitations. The ‘gold’ standard to estimate the portion of a contaminant that reaches the system circulatory system (BA) of its receptor is to determine BA in an in vivo system. Various animal models have been utilised for this purpose. Because of animal ethics issues, and the expenses associated with performing in vivo studies, several in vitro methods have been developed to determine BAC as a surrogate model for the estimation of BA. However, few in vitro BAC studies have been calibrated against a reliable animal model, such as immature swine. In this review, we have identified suitable methods for assessing arsenic and lead BAC and proposed a decision tree for the determination of contaminant bioavailability and bioaccessibility for health risk assessment.
Keyword Bioavailability
Bioaccessibility
Metals
Metalloids
Risk assessment
Site contamination
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 14 June 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
National Research Centre for Environmental Toxicology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 22 times in Scopus Article | Citations
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Created: Thu, 16 Jan 2014, 18:28:59 EST by Robyne Anderson on behalf of National Res Centre For Environmental Toxicology