Comparison of the sex-specific associations between systolic blood pressure and the risk of cardiovascular disease: A systematic review and meta-analysis of 124 cohort studies, including 1.2 million individuals

Peters, Sanne A. E., Huxley, Rachel R. and Woodward, Mark (2013) Comparison of the sex-specific associations between systolic blood pressure and the risk of cardiovascular disease: A systematic review and meta-analysis of 124 cohort studies, including 1.2 million individuals. Stroke, 44 9: 2394-2401. doi:10.1161/STROKEAHA.113.001624


Author Peters, Sanne A. E.
Huxley, Rachel R.
Woodward, Mark
Title Comparison of the sex-specific associations between systolic blood pressure and the risk of cardiovascular disease: A systematic review and meta-analysis of 124 cohort studies, including 1.2 million individuals
Journal name Stroke   Check publisher's open access policy
ISSN 0039-2499
1524-4628
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1161/STROKEAHA.113.001624
Open Access Status DOI
Volume 44
Issue 9
Start page 2394
End page 2401
Total pages 8
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams and Wilkins
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
2728 Clinical Neurology
2902 Advanced and Specialised Nursing
Abstract Background and Purpose - Conflicting results have been reported on whether the association between increments in systolic blood pressure (SBP) and cardiovascular disease differs between men and women. We performed a systematic review with meta-analysis to compare reliably sex-specific associations between SBP and cardiovascular risk. Methods - PubMed MEDLINE was systematically searched for prospective population-based cohort studies published between January 1, 1966, and March 31, 2012. Studies were selected if they presented sex-specific estimates, with associated variability, of the relative risk for either ischemic heart disease or stroke according to SBP. The data were pooled using random effects models with inverse variance weighting, and estimates of the ratio of the relative risks per 10 mm Hg increment in SBP, comparing women with men, were derived. Results - Data from 124 prospective cohort studies, including information on 1197 472 individuals (44% women) and 26 176 stroke and 24 434 ischemic heart disease events, were included. Overall, there was no evidence to suggest a sex difference in the relationship between SBP and either the risk of stroke (pooled ratio of relative risks, 0.98 [95% confidence interval, 0.96; 1.01]; P=0.13) or ischemic heart disease (pooled ratio of relative risks, 1.00 [95% confidence interval, 0.97; 1.04]; P=0.85). Conclusions - Elevated levels of SBP are a major risk factor for stroke and ischemic heart diseases in both women and men. This study unequivocally demonstrates the broadly similar impact of SBP increments on cardiovascular outcomes in both sexes.
Keyword Blood pressure
Cardiovascular diseases
Meta analysis
Risk factors
Sex differences
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
 
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Created: Wed, 15 Jan 2014, 19:31:07 EST by Ms Kate Rowe on behalf of School of Public Health