Localized suppression of inflammation at sites of Helicobacter pylori colonization

Every, Alison L., Ng, Garrett Z., Skene, Caroline D., Harbour, Stacey N., Walduck, Anna K., McGuckin, Michael A. and Sutton, Philip (2011) Localized suppression of inflammation at sites of Helicobacter pylori colonization. Infection and Immunity, 79 10: 4186-4192. doi:10.1128/IAI.05602-11

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Author Every, Alison L.
Ng, Garrett Z.
Skene, Caroline D.
Harbour, Stacey N.
Walduck, Anna K.
McGuckin, Michael A.
Sutton, Philip
Title Localized suppression of inflammation at sites of Helicobacter pylori colonization
Formatted title
Localized suppression of inflammation at sites of Helicobacter pylori colonization
Journal name Infection and Immunity   Check publisher's open access policy
ISSN 1098-5522
Publication date 2011-10-01
Year available 2011
Sub-type Article (original research)
DOI 10.1128/IAI.05602-11
Open Access Status File (Publisher version)
Volume 79
Issue 10
Start page 4186
End page 4192
Total pages 7
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
While gastric adenocarcinoma is the most serious consequence of Helicobacter pylori infection, not all infected persons develop this pathology. Individuals most at risk of this cancer are those in whom the bacteria colonize the acid-secreting region of the stomach and subsequently develop severe inflammation in the gastric corpus. It has been reported anecdotally that male mice become infected with greater numbers of H. pylori bacteria than female mice. While investigating this phenomenon, we found that increased H. pylori infection densities in male mice were not related to antibody production, and this phenomenon was not normalized by gonadectomy. However, the gastric pH in male 129/Sv mice was significantly elevated compared with that in female mice. Differences in colonization were evident within 1 day postinfection and significantly arose due to colonization of the gastric corpus region in male mice. This provided a potential model for comparing the effect of corpus colonization on the development of gastritis. This was explored using two models of H. pylori-induced inflammation, namely, 2-month infections of Muc1−/− mice and 6-month infections of wild-type 129/Sv mice. While H. pylori infection of female mice induced a severe, corpus-predominant atrophic gastritis, to our surprise, male mice developed minimal inflammation despite being colonized with significantly more H. pylori bacteria than female controls. Thus, colonization of the gastric corpus in male mice was associated with a loss of inflammation in that region. The suppression of inflammation concomitant with infection of the gastric corpus in male mice demonstrates a powerful localized suppression of inflammation induced at sites of H. pylori colonization.
Keyword Immunology
Infectious Diseases
Infectious Diseases
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 543704
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Jan 2014, 03:35:37 EST by Michael Mcguckin on behalf of School of Biomedical Sciences