Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery

Hartono, Sandy Budi, Phuoc, Nghia Truong, Yu, Meihua, Jia, Zhongfan, Monteiro, Michael J., Qiao, Shizhang and Yu, Chengzhong (2014) Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery. Journal of Materials Chemistry B, 2 16: 718-726. doi:10.1039/C3TB21015D

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Author Hartono, Sandy Budi
Phuoc, Nghia Truong
Yu, Meihua
Jia, Zhongfan
Monteiro, Michael J.
Qiao, Shizhang
Yu, Chengzhong
Title Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery
Journal name Journal of Materials Chemistry B   Check publisher's open access policy
ISSN 2050-750X
2050-7518
Publication date 2014-02-01
Year available 2013
Sub-type Article (original research)
DOI 10.1039/C3TB21015D
Open Access Status File (Author Post-print)
Volume 2
Issue 16
Start page 718
End page 726
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Language eng
Abstract Novel mesoporous silica nanoparticles (LPMSNs) functionalised with degradable poly(2-dimethylaminoethyl acrylate) (PDMAEA) have been developed (PDMAEA–LPMSNs) as nano-carriers for gene delivery. The unique design of PDMAEA–LPMSNs has endowed this system with multiple functions derived from both the organic and inorganic moieties. The cationic polymer unit binds to genetic molecules and undergoes a self-catalyzed hydrolysis in water to form a non-toxic anionic polymer poly(acrylic acid), allowing controlled release of siRNA in the cells. The nanopores of the LPMSNs provide a reservoir for storage and release of chloroquine to facilitate endosomal escape. The PDMAEA–LPMSN composites were characterized by elemental analysis (EA), X-ray photoelectron spectroscopy (XPS), solid-state 13C magic-angle spinning nuclear magnetic resonance (MAS-NMR), thermogravimetric analysis (TGA), and nitrogen sorption techniques. Their siRNA delivery performance was tested in a KHOS cell line, showing promising potential for co-delivery of genes and drugs.
Keyword Materials Science, Biomaterials
Materials Science
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online: 12 November 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Tue, 14 Jan 2014, 21:59:19 EST by Cathy Fouhy on behalf of Aust Institute for Bioengineering & Nanotechnology