Tissue composition changes and secondary lymphedema

Dylke, E. S., Ward, L. C., Meerkin, J. D., Nery, L. and Kilbreath, S. L. (2013) Tissue composition changes and secondary lymphedema. Lymphatic Research and Biology, 11 4: 211-218. doi:10.1089/lrb.2013.0018

Author Dylke, E. S.
Ward, L. C.
Meerkin, J. D.
Nery, L.
Kilbreath, S. L.
Title Tissue composition changes and secondary lymphedema
Journal name Lymphatic Research and Biology   Check publisher's open access policy
ISSN 1539-6851
Publication date 2013-12-01
Sub-type Article (original research)
DOI 10.1089/lrb.2013.0018
Open Access Status Not Open Access
Volume 11
Issue 4
Start page 211
End page 218
Total pages 8
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Language eng
Formatted abstract
Background: The aim of this study was to determine the impact of dominance and severity on tissue composition changes with lymphedema using dual-energy X-ray absorptiometry (DXA), and to determine the relationships between the DXA-determined tissue volumes and the clinical outcomes determined by perometry and bioimpedance spectroscopy.

Methods and Results: Fifty-six women with secondary lymphedema and 44 women without a history of breast cancer or lymphedema underwent measurement of their upper limbs with DXA, perometry, and bioimpedance spectroscopy. Whether the affected side was the dominant or nondominant arm influenced inter-limb tissue volumes differences (F=16.31 to 35.14; all p<0.001) and interacted with the severity of lymphedema (F=3.22 to 11.07; all p<0.05). In the control group, the dominant limb had more lean tissue but less fat than the nondominant limb. In the lymphedema group, increases in fat in the affected arm were not related to generalized increases in whole body adiposity when the dominant arm was affected. Perometry-measured volumes and BIS ratios were moderately to highly correlated with inter-limb fat, volume, and total tissue differences found by DXA (r=0.39 to 0.86).

Conclusions: The direction and magnitude of limb composition changes in those with lymphedema are impacted by whether the affected side is the dominant or nondominant limb, as well as the severity of the condition. The stage of tissue composition change may impact on the diagnosis and monitoring as well as treatment of secondary lymphedema.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
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