The dose–response relationship between pseudoephedrine ingestion and exercise performance

Pritchard-Peschek, Kellie, Jenkins, David G., Osborne, Mark A., Slater, Gary J. and Taaffe, Dennis R. (2013) The dose–response relationship between pseudoephedrine ingestion and exercise performance. Journal of Science and Medicine in Sport, 17 5: 531-534. doi:10.1016/j.jsams.2013.07.015

Author Pritchard-Peschek, Kellie
Jenkins, David G.
Osborne, Mark A.
Slater, Gary J.
Taaffe, Dennis R.
Title The dose–response relationship between pseudoephedrine ingestion and exercise performance
Journal name Journal of Science and Medicine in Sport   Check publisher's open access policy
ISSN 1440-2440
Publication date 2013-08-08
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.jsams.2013.07.015
Open Access Status Not yet assessed
Volume 17
Issue 5
Start page 531
End page 534
Total pages 4
Place of publication Chatswood, NSW Australia
Publisher Elsevier
Language eng
Formatted abstract
Objectives: The purpose of the present study was to examine a possible dose–response between pre-exercise pseudoephedrine intake and cycling time trial performance.Methods: Ten trained male endurance cyclists (26.5 ± 6.2 years, 75.1 ± 5.9 kg, 70.6 ± 6.8 mL kg−1min−1)undertook three cycling time trials in which a fixed amount of work (7 kJ kg−1body mass) was completedin the shortest possible time. Sixty minutes before the start of exercise, subjects orally ingested either 2.3 mg kg−1or 2.8 mg kg−1body mass of pseudoephedrine or a placebo in a randomised and double-blind manner. Venous blood was sampled at baseline, pre- and post-warm up and post-exercise forthe analysis of pH and lactate and glucose concentrations; plasma catecholamine and pseudoephedrineconcentrations were measured at all times except post-warm up.
Results: Cycling time trial performance (∼30 min) was not enhanced by pseudoephedrine ingestion.Plasma pseudoephedrine concentration increased from pre-warm up to post-exercise in both treatment conditions, with the 2.8 mg kg−1body mass dose producing the highest concentration at both time points(2.8 mg kg−1> 2.3 mg kg−1> placebo; p < 0.001).
Conclusions: There was large individual variation in plasma pseudoephedrine concentration betweensubjects following pseudoephedrine administration. A number of factors clearly influence the uptakeand appearance of pseudoephedrine in the blood and these are not yet fully understood. Combined withsubsequent differences in plasma pseudoephedrine between individuals, this may partially explain thepresent findings and also the inconsistencies in performance following pseudoephedrine administrationin previous studies.
Keyword Sport Sciences
Sport Sciences
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes In Press, Corrected Proof Available online 8 August 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Human Movement and Nutrition Sciences Publications
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Created: Mon, 13 Jan 2014, 05:52:51 EST by Deborah Noon on behalf of School of Human Movement and Nutrition Sciences