An iron-regulated LysR-type element mediates antimicrobial peptide resistance and virulence in Yersinia pseudotuberculosis

Arafah, Sonia, Rosso, Marie-Laure, Rehaume, Linda, Hancock, Robert E. W., Simonet, Michel and Marceau, Michae (2009) An iron-regulated LysR-type element mediates antimicrobial peptide resistance and virulence in Yersinia pseudotuberculosis. Microbiology, 155 7: 2168-2181. doi:10.1099/mic.0.026690-0


Author Arafah, Sonia
Rosso, Marie-Laure
Rehaume, Linda
Hancock, Robert E. W.
Simonet, Michel
Marceau, Michae
Title An iron-regulated LysR-type element mediates antimicrobial peptide resistance and virulence in Yersinia pseudotuberculosis
Journal name Microbiology   Check publisher's open access policy
ISSN 1350-0872
1465-2080
Publication date 2009-01-01
Sub-type Article (original research)
DOI 10.1099/mic.0.026690-0
Open Access Status DOI
Volume 155
Issue 7
Start page 2168
End page 2181
Total pages 14
Place of publication Reading, Berks, United Kingdom
Publisher Society for General Microbiology
Language eng
Abstract During the course of its infection of the mammalian digestive tract, the entero-invasive, Gram-negative bacterium Yersinia pseudotuberculosis must overcome various hostile living conditions (notably, iron starvation and the presence of antimicrobial compounds produced in situ). We have previously reported that in vitro bacterial growth during iron deprivation raises resistance to the antimicrobial peptide polymyxin B; here, we show that this phenotype is mediated by a chromosomal gene (YPTB0333) encoding a transcriptional regulator from the LysR family. We determined that the product of YPTB0333 is a pleiotropic regulator which controls (in addition to its own expression) genes encoding the Yfe iron-uptake system and polymyxin B resistance. Lastly, by using a mouse model of oral infection, we demonstrated that YPTB0333 is required for colonization of Peyer's patches and mesenteric lymph nodes by Y. pseudotuberculosis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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