Modeling of the hemodynamic responses in block design fMRI studies

Shan, Zuyao Y., Wright, Margaret J., Thompson, Paul M., McMahon, Katie L., Blokland, Gabriella G. A. M., de Zubicaray, Greig I., Martin, Nicholas G., Vinkhuyzen, Anna A. E. and Reutens, David C. (2014) Modeling of the hemodynamic responses in block design fMRI studies. Journal of Cerebral Blood Flow and Metabolism, 34 2: 316-324. doi:10.1038/jcbfm.2013.200

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Author Shan, Zuyao Y.
Wright, Margaret J.
Thompson, Paul M.
McMahon, Katie L.
Blokland, Gabriella G. A. M.
de Zubicaray, Greig I.
Martin, Nicholas G.
Vinkhuyzen, Anna A. E.
Reutens, David C.
Title Modeling of the hemodynamic responses in block design fMRI studies
Journal name Journal of Cerebral Blood Flow and Metabolism   Check publisher's open access policy
ISSN 0271-678X
1559-7016
Publication date 2014-02-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/jcbfm.2013.200
Open Access Status File (Author Post-print)
Volume 34
Issue 2
Start page 316
End page 324
Total pages 9
Place of publication New York, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
The hemodynamic response function (HRF) describes the local response of brain vasculature to functional activation. Accurate HRF modeling enables the investigation of cerebral blood flow regulation and improves our ability to interpret fMRI results. Block designs have been used extensively as fMRI paradigms because detection power is maximized; however, block designs are not optimal for HRF parameter estimation. Here we assessed the utility of block design fMRI data for HRF modeling. The trueness (relative deviation), precision (relative uncertainty), and identifiability (goodness-of-fit) of different HRF models were examined and test–retest reproducibility of HRF parameter estimates was assessed using computer simulations and fMRI data from 82 healthy young adult twins acquired on two occasions 3 to 4 months apart. The effects of systematically varying attributes of the block design paradigm were also examined. In our comparison of five HRF models, the model comprising the sum of two gamma functions with six free parameters had greatest parameter accuracy and identifiability. Hemodynamic response function height and time to peak were highly reproducible between studies and width was moderately reproducible but the reproducibility of onset time was low. This study established the feasibility and test–retest reliability of estimating HRF parameters using data from block design fMRI studies.

Data acquisition and analysis were supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development (Grant RO1HD050735) and National Health and Medical Research Council, Australia (Project Grant 496682 and Program Grant 628952).
Keyword fMRI
Hemodynamic response
Hemodynamic response function
Test–retest reliability
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 20 November 2013

 
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Created: Thu, 09 Jan 2014, 02:18:55 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging