Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010

Blencowe, Hannah, Lee, Anne C. C., Cousens, Simon, Bahalim, Adil, Narwal, Rajesh, Zhong, Nanbert, Chou, Doris, Say, Lale, Modi, Neena, Katz, Joanne, Vos, Theo, Marlow, Neil and Lawn, Joy E. (2013) Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010. Pediatric Research, 74 Suppl.1: 17-34. doi:10.1038/pr.2013.204


Author Blencowe, Hannah
Lee, Anne C. C.
Cousens, Simon
Bahalim, Adil
Narwal, Rajesh
Zhong, Nanbert
Chou, Doris
Say, Lale
Modi, Neena
Katz, Joanne
Vos, Theo
Marlow, Neil
Lawn, Joy E.
Title Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
1530-0447
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/pr.2013.204
Open Access Status DOI
Volume 74
Issue Suppl.1
Start page 17
End page 34
Total pages 18
Place of publication New York, NY United States
Publisher Nature Publishing Group
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
Abstract Background: In 2010, there were an estimated 15 million preterm births worldwide (<37 wk gestation). Survivors are at risk of adverse outcomes, and burden estimation at global and regional levels is critical for priority setting. Methods: Systematic reviews and meta-analyses were undertaken to estimate the risk of long-term neurodevelopmental impairment for surviving preterm babies according to the level of care. A compartmental model was used to estimate the number of impaired postneonatal survivors following preterm birth in 2010. A separate model (DisMod-MR) was used to estimate years lived with disability (YLDs) for the global burden of disease 2010 study. Disability adjusted life years (DALYs) were calculated as the sum of YLDs and years of life lost (YLLs). Results: In 2010, there were an estimated 13 million preterm births who survived beyond the first month. Of these, 345,000 (2.7%, uncertainty range: 269,000-420,000) were estimated to have moderate or severe neurodevelopmental impairment, and a further 567,000 (4.4%, (445,000-732,000)) were estimated to have mild neurodevelopmental impairment. Many more have specific learning or behavioral impairments or reduced physical or mental health. Fewest data are available where the burden is heaviest. Preterm birth was responsible for 77 million DALYs, 3.1% of the global total, of which only 3 million were YLDs. Conclusion: Most preterm births (>90%) survive without neurodevelopmental impairment. Developing effective means of prevention of preterm birth should be a longer term priority, but major burden reduction could be made immediately with improved coverage and quality of care. Improved newborn care would reduce mortality, especially in low-income countries and is likely to reduce impairment in survivors, particularly in middle-income settings. Copyright
Keyword Preterm birth
Postnatal care
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
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