Relaxin-3/RXFP3 system regulates alcohol-seeking

Ryan,Philip J., Kastman, Hanna E., Krstew, Elena V., Rosengren, K. Johan, Hossain, Mohammed Akhter, Churilov, Leonid, Wade, John D., Gundlach, Andrew L. and Lawrence, Andrew J. (2013) Relaxin-3/RXFP3 system regulates alcohol-seeking. Proceedings of the National Academy of Sciences of the United States of America, 110 51: 20789-20794. doi:10.1073/pnas.1317807110

Author Ryan,Philip J.
Kastman, Hanna E.
Krstew, Elena V.
Rosengren, K. Johan
Hossain, Mohammed Akhter
Churilov, Leonid
Wade, John D.
Gundlach, Andrew L.
Lawrence, Andrew J.
Title Relaxin-3/RXFP3 system regulates alcohol-seeking
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
Publication date 2013-12-17
Year available 2013
Sub-type Article (original research)
DOI 10.1073/pnas.1317807110
Open Access Status DOI
Volume 110
Issue 51
Start page 20789
End page 20794
Total pages 6
Place of publication Washington, DC United States
Publisher National Academy of Sciences
Language eng
Subject 1000 General
Abstract Relapse and hazardous drinking represent the most difficult clinical problems in treating patients with alcohol use disorders. Using a rat model of alcohol use and alcohol-seeking, we demonstrated that central administration of peptide antagonists for relaxin family peptide 3 receptor (RXFP3), the cognate receptor for the highly conserved neuropeptide, relaxin-3, decreased self-administration of alcohol in a dose-related manner and attenuated cue-and stress-induced reinstatement following extinction. By comparison, RXFP3 antagonist treatment did not significantly attenuate self-administration or reinstatement of sucrose-seeking, suggesting a selective effect for alcohol. RXFP3 is densely expressed in the stress-responsive bed nucleus of the stria terminalis, and bilateral injections of RXFP3 antagonist into the bed nucleus of the stria terminalis significantly decreased self-administration and stress-induced reinstatement of alcohol, suggesting that this brain region may, at least in part, mediate the effects of RXFP3 antagonism. RXFP3 antagonist treatment had no effect on general ingestive behavior, activity, or procedural memory for lever pressing in the paradigms assessed. These data suggest that relaxin-3/RXFP3 signaling regulates alcohol intake and relapse-like behavior, adding to current knowledge of the brain chemistry of reward-seeking.
Keyword Addiction
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 508976
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
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