Targeted multimodal liposomes for nano-delivery and imaging: An avenger for drug resistance and cancer

Gurudevan, Sneha, Kanwar, Rupinder K., Veedu, Rakesh N., Sasidharan, Sreenivasan, Kennedy, Richard L., Walder, Ken, Prasad, Neerati and Kanwar, Jagat R. (2013) Targeted multimodal liposomes for nano-delivery and imaging: An avenger for drug resistance and cancer. Current Gene Therapy, 13 5: 322-334. doi:10.2174/156652321305131212123558

Author Gurudevan, Sneha
Kanwar, Rupinder K.
Veedu, Rakesh N.
Sasidharan, Sreenivasan
Kennedy, Richard L.
Walder, Ken
Prasad, Neerati
Kanwar, Jagat R.
Title Targeted multimodal liposomes for nano-delivery and imaging: An avenger for drug resistance and cancer
Journal name Current Gene Therapy   Check publisher's open access policy
ISSN 1566-5232
Publication date 2013-01-01
Sub-type Article (original research)
DOI 10.2174/156652321305131212123558
Open Access Status Not Open Access
Volume 13
Issue 5
Start page 322
End page 334
Total pages 13
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Abstract Understanding the cellular target structure and thereby proposing the best delivery system to achieve sustained release of drugs has always been a significant area of focus in biomedical research for translational benefits. Specific targeting of the receptors expressed on the target cell represents an effective strategy for increasing the pharmacological efficacy of the administered drug. Liposomes offer enhanced conveyance as a potential carrier of biomacromolecules such as anti-cancer proteins, drugs and siRNA for targeting tumour cell death. Commonly used liposomal constructs for various therapies are Doxil, Myocet, DepoCyt and Abraxanes. However, recent strategy of using multifunctional liposomes for the sustained release of drugs with increased plasma residence time and monoclonal antibody-based targeting of tumours coupled with imaging modalities have attracted enormous scientific attention. The ability of liposomes coated with specific ligands such as Apo-E derived RGD R9 and Tat peptide, to reverse the conceptualisation of drug resistance and cross the blood brain barrier, provides promising future for their use as an efficient drug delivery system. By outlining the recent advancements and innovations in the established concept of liposomal drug delivery, this review will focus on the multifunctional liposomes as an emerging novel lipid based drug delivery system.
Keyword Immunoliposomes and gene transfer
Multidrug resistance
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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