MYB down-regulation enhances sensitivity of U937 myeloid leukemia cells to the histone deacetylase inhibitor LBH589 in vitro and in vivo

Ye, Ping, Zhao, Liang, McGirr, Crystal and Gonda, Thomas J. (2014) MYB down-regulation enhances sensitivity of U937 myeloid leukemia cells to the histone deacetylase inhibitor LBH589 in vitro and in vivo. Cancer Letters, 343 1: 98-106. doi:10.1016/j.canlet.2013.09.022


Author Ye, Ping
Zhao, Liang
McGirr, Crystal
Gonda, Thomas J.
Title MYB down-regulation enhances sensitivity of U937 myeloid leukemia cells to the histone deacetylase inhibitor LBH589 in vitro and in vivo
Journal name Cancer Letters   Check publisher's open access policy
ISSN 0304-3835
1872-7980
Publication date 2014-02-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.canlet.2013.09.022
Volume 343
Issue 1
Start page 98
End page 106
Total pages 9
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier Ireland Ltd.
Language eng
Subject 1306 Cancer Research
2730 Oncology
Abstract The effect of combining MYB suppression with the histone deacetylase inhibitor LBH589 was studied in human myeloid leukemia cell lines. MYB knockdown inhibited proliferation and induced apoptosis in U937 and K562 cells in vitro, and also sensitized both to the pro-apoptotic effect of LBH589. This was accompanied by enhanced expression of the pro-apoptotic BCL2 family members BOK and BIM. U937 cells carrying inducible MYB shRNA were also transplanted into NOD/SCID mice. The combination of MYB knockdown and LBH589 prolonged survival compared to either treatment alone, suggesting that further development of such combinations might lead to effective and safe leukemia therapies.
Keyword AML
Apoptosis
LBH589/Panobinostat
MYB
Xenograft
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 07 Jan 2014, 10:16:46 EST by System User on behalf of School of Pharmacy