Expression of beta-catenin and mesenchymal markers in canine prostatic hyperplasia and carcinoma

Lean, F. Z. X., Kontos, S. and Palmieri, C. (2014) Expression of beta-catenin and mesenchymal markers in canine prostatic hyperplasia and carcinoma. Journal of Comparative Pathology, 150 4: 373-381. doi:10.1016/j.jcpa.2013.12.008

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Lean, F. Z. X.
Kontos, S.
Palmieri, C.
Title Expression of beta-catenin and mesenchymal markers in canine prostatic hyperplasia and carcinoma
Formatted title
Expression of β-catenin and mesenchymal markers in canine prostatic hyperplasia and carcinoma
Journal name Journal of Comparative Pathology   Check publisher's open access policy
ISSN 0021-9975
1532-3129
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.jcpa.2013.12.008
Open Access Status Not Open Access
Volume 150
Issue 4
Start page 373
End page 381
Total pages 9
Place of publication Camden, London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
β-catenin is a nuclear signalling molecule that is associated with human prostatic neoplasia and the epithelial–mesenchymal transition process. The present study evaluates immunohistochemically the expression of β-catenin and the mesenchymal markers vimentin, desmin, calponin and smooth muscle actin (SMA) in four normal canine prostates and prostate samples from 15 dogs with benign prostatic hyperplasia (BPH) and six with prostatic carcinoma (PC). β-catenin was located on the membrane of normal epithelial cells, while the same marker had both cytoplasmic and membrane expression in hyperplastic cells and a nuclear redistribution in PC. Vimentin-positive luminal cells were observed in two of the 15 cases ofBPH and in all PC samples, suggesting the conversion of neoplastic epithelial cells to a mesenchymal type. SMA was consistently negative in PC, but there was mild desmin and calponin immunoreactivity in these lesions. As in men, β-catenin is involved in canine prostatic carcinogenesis, thus further validating the use of this animal model to study human prostatic disease.
Keyword beta-Catenin
Epithelial–mesenchymal transition
Prostate
Dog
β-Catenin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 27 December 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Veterinary Science Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 07 Jan 2014, 05:27:17 EST by Chiara Palmieri on behalf of School of Veterinary Science