Characterization of cytoplasmic hyaline bodies in a hepatocellular carcinoma of a dog

Masserdotti, Carlo, Rossetti, Enrica, De Lorenzi, Davide, Della Salda, Leonardo and Palmieri, Chiara (2013) Characterization of cytoplasmic hyaline bodies in a hepatocellular carcinoma of a dog. Research in Veterinary Science, 96 1: 143-146. doi:10.1016/j.rvsc.2013.11.016

Author Masserdotti, Carlo
Rossetti, Enrica
De Lorenzi, Davide
Della Salda, Leonardo
Palmieri, Chiara
Title Characterization of cytoplasmic hyaline bodies in a hepatocellular carcinoma of a dog
Journal name Research in Veterinary Science   Check publisher's open access policy
ISSN 0034-5288
Publication date 2013-12-09
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.rvsc.2013.11.016
Open Access Status Not yet assessed
Volume 96
Issue 1
Start page 143
End page 146
Total pages 4
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Subject 3400 Veterinary
Abstract This report describes the morphological and immunohistochemical features of intracytoplasmic inclusion bodies found in a 13-year-old Yorkshire dog with a hepatocellular carcinoma and referred for anorexia, lethargy and mild polydipsia. Fine-needle aspirates of the large abdominal mass revealed high number of pleomorphic neoplastic hepatocytes, containing round to polygonal, well-demarcated, hyaline bodies. Same findings were histologically confirmed on multiple biopsies. Immunohistochemically, the inclusion bodies were negative for alpha-1-antitrypsin, carcinoembryonary antigen, fibrinogen, IgG, IgM, cytokeratins 7, 8, 18, 19, 20. By transmission electron microscopy, the cytoplasmic inclusions were composed of granular homogeneous or reticulated electrondense matrix, enclosed within dilated rough endoplasmic reticulum or remnants of its membranes, consistent with proteinaceous material accumulated within neoplastic hepatocytes due to aberrant protein secretion or transport. This is the first detailed characterization of hyaline cytoplasmic inclusion bodies in canine hepatocellular carcinoma.
Keyword Liver
Hepatocellular carcinoma
Inclusion bodies
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 9 December 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Veterinary Science Publications
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Created: Tue, 07 Jan 2014, 05:25:44 EST by Chiara Palmieri on behalf of School of Veterinary Science