Molecular nanoshearing: an innovative approach to shear off molecules with AC-induced nanoscopic fluid flow

Shiddiky, Muhammad J. A., Vaidyanathan, Ramanathan, Rauf, Sakandar, Tay, Zhikay and Trau, Matt (2014) Molecular nanoshearing: an innovative approach to shear off molecules with AC-induced nanoscopic fluid flow. Scientific Reports, 4 3716.1-3716.7. doi:10.1038/srep03716


Author Shiddiky, Muhammad J. A.
Vaidyanathan, Ramanathan
Rauf, Sakandar
Tay, Zhikay
Trau, Matt
Title Molecular nanoshearing: an innovative approach to shear off molecules with AC-induced nanoscopic fluid flow
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2014-01-16
Year available 2014
Sub-type Article (original research)
DOI 10.1038/srep03716
Open Access Status DOI
Volume 4
Start page 3716.1
End page 3716.7
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Early diagnosis of disease requires highly specific measurement of molecular biomarkers from femto to pico-molar concentrations in complex biological (e.g., serum, blood, etc.) samples to provide clinically useful information. While reaching this detection limit is challenging in itself, these samples contain numerous other non-target molecules, most of which have a tendency to adhere to solid surfaces via nonspecific interactions. Herein, we present an entirely new methodology to physically displace nonspecifically bound molecules from solid surfaces by utilizing a newly discovered ‘‘tuneable force’’, induced by an applied alternating electric field, which occurs within few nanometers of an electrode surface. This methodology thus offers a unique ability to shear-off loosely bound molecules from the solid/liquid interface. Via this approach, we achieved a 5-fold reduction in nonspecific adsorption of non-target protein molecules and a 1000-fold enhancement for the specific capture of HER2 protein in human serum.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published 16 January 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 01 Jan 2014, 06:30:32 EST by Ramanathan Pudhukode Vaidyanathan on behalf of Aust Institute for Bioengineering & Nanotechnology