Targeting iron uptake to control Pseudomonas aeruginosa infections in cystic fibrosis

Smith, Daniel J., Lamont, Iain L., Anderson, Greg J. and Reid, David W. (2013) Targeting iron uptake to control Pseudomonas aeruginosa infections in cystic fibrosis. European Respiratory Journal, 42 6: 1723-1736. doi:10.1183/09031936.00124012


Author Smith, Daniel J.
Lamont, Iain L.
Anderson, Greg J.
Reid, David W.
Title Targeting iron uptake to control Pseudomonas aeruginosa infections in cystic fibrosis
Formatted title
Targeting iron uptake to control Pseudomonas aeruginosa infections in cystic fibrosis
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
1399-3003
Publication date 2013-12-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1183/09031936.00124012
Open Access Status Not Open Access
Volume 42
Issue 6
Start page 1723
End page 1736
Total pages 14
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Formatted abstract
The aerobic Gram-negative bacterium Pseudomonas aeruginosa is an opportunistic pathogen responsible for life-threatening acute and chronic infections in humans. As part of chronic infection P. aeruginosa forms biofilms, which shield the encased bacteria from host immune clearance and provide an impermeable and protective barrier against currently available antimicrobial agents.

P. aeruginosa
has an absolute requirement for iron for infection success. By influencing cell-cell communication (quorum sensing) and virulence factor expression, iron is a powerful regulator of P. aeruginosa behaviour. Consequently, the imposed perturbation of iron acquisition systems has been proposed as a novel therapeutic approach to the treatment of P. aeruginosa biofilm infection.

In this review, we explore the influence of iron availability on P. aeruginosa infection in the lungs of the people with the autosomal recessive condition cystic fibrosis as an archetypal model of chronic P. aeruginosa biofilm infection. Novel therapeutics aimed at disrupting P. aeruginosa are discussed, with an emphasis placed on identifying the barriers that need to be overcome in order to translate these promising in vitro agents into effective therapies in human pulmonary infections.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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