Causes of death in a cohort treated for opioid dependence between 1985 and 2005

Degenhardt, Louisa, Larney, Sarah, Randall, Debotah, Burns, Lucy and Hall, Wayne (2014) Causes of death in a cohort treated for opioid dependence between 1985 and 2005. Addiction, 109 1: 90-99. doi:10.1111/add.12337

Author Degenhardt, Louisa
Larney, Sarah
Randall, Debotah
Burns, Lucy
Hall, Wayne
Title Causes of death in a cohort treated for opioid dependence between 1985 and 2005
Journal name Addiction   Check publisher's open access policy
ISSN 0965-2140
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1111/add.12337
Open Access Status Not yet assessed
Volume 109
Issue 1
Start page 90
End page 99
Total pages 10
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
Language eng
Subject 2701 Medicine (miscellaneous)
2738 Psychiatry and Mental health
Abstract Aims: To examine changes in causes of death in a cohort treated for opioid dependence, across time and age; quantify years of potential life lost (YPLL); and identify avoidable causes of death. Design: People in New South Wales (NSW) who registered for opioid substitution therapy (OST), 1985-2005, were linked to a register of all deaths in Australia. Setting: NSW, Australia. Measurements: Crude mortality rates (CMRs), age-sex-standardized mortality rates (ASSRs) and standardized mortality ratios (SMRs) across time, sex and age. Years of potential life lost (YPLL) were calculated with reference to Australian life tables and by calculating years lost before the age of 65 years. Findings: There were 43789 people in the cohort, with 412216 person-years of follow-up. The proportion of the cohort aged 40+ years increased from 1% in 1985 to 39% in 2005. Accidental opioid overdoses, suicides, transport accidents and violent deaths declined with age; deaths from cardiovascular disease, liver disease and cancer increased. Among men, 89% of deaths were potentially avoidable; among women, 86% of deaths were avoidable. There were an estimated 160555 YPLL in the cohort, an average of 44 YPLL per decedent and an average of 29 YPLL before age 65 years. Conclusions: Among a cohort of opioid-dependent people in New South Wales, 1985-2005, almost nine in 10 deaths in the cohort were avoidable. There is huge scope to improve mortality among opioid-dependent people.
Keyword Ageing
Injecting drug use
Opioid dependence
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 455451
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 40 times in Scopus Article | Citations
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