The non-coding road towards cardiac regeneration

Hudson, James E. and Porrello, Enzo R. (2013) The non-coding road towards cardiac regeneration. Journal of Cardiovascular Translational Research, 6 6: 909-923. doi:10.1007/s12265-013-9486-8

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Author Hudson, James E.
Porrello, Enzo R.
Title The non-coding road towards cardiac regeneration
Journal name Journal of Cardiovascular Translational Research   Check publisher's open access policy
ISSN 1937-5387
1937-5395
Publication date 2013-12-01
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s12265-013-9486-8
Open Access Status Not yet assessed
Volume 6
Issue 6
Start page 909
End page 923
Total pages 15
Place of publication New York, NY, United States
Publisher Springer
Language eng
Abstract Our understanding of cardiovascular disease has evolved rapidly, leading to a number of treatments that have improved patient quality of life and mortality rates. However, there is still no cure for heart failure. This has led to the pursuit of cardiac regeneration to prevent, and ultimately cure, this debilitating condition. To this end, several approaches have been proposed, including activation of cardiomyocyte proliferation, activation of endogenous or exogenous stem/progenitor cells, delivery of de novo cardiomyocytes, and in situ direct reprogramming of cardiac fibroblasts. While these different methodologies are currently being intensely investigated, there are still a number of caveats limiting their application in the clinic. Given the emerging regulatory potential of non-coding RNAs for controlling diverse cellular processes, these molecules may offer potential solutions in this pursuit of cardiac regeneration. In this concise review, we discuss the potential role of non-coding RNAs in a variety of different cardiac regenerative approaches.
Keyword MicroRNA
Long noncoding RNA (lncRNA)
Cardiac progenitor cells
Cardiomyocyte proliferation
Direct reprogramming
Stem cells
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID APP1053089
APP1033815
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
School of Medicine Publications
 
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