The genomic distribution of sex-biased genes in Drosophila serrata: X chromosome demasculinization, feminization, and hyperexpression in both sexes

Allen, Scott L., Bonduriansky, Russell and Chenoweth, Stephen F. (2013) The genomic distribution of sex-biased genes in Drosophila serrata: X chromosome demasculinization, feminization, and hyperexpression in both sexes. Genome Biology and Evolution, 5 10: 1986-1994. doi:10.1093/gbe/evt145


Author Allen, Scott L.
Bonduriansky, Russell
Chenoweth, Stephen F.
Title The genomic distribution of sex-biased genes in Drosophila serrata: X chromosome demasculinization, feminization, and hyperexpression in both sexes
Formatted title
The genomic distribution of sex-biased genes in Drosophila serrata: X chromosome demasculinization, feminization, and hyperexpression in both sexes
Journal name Genome Biology and Evolution   Check publisher's open access policy
ISSN 1759-6653
Publication date 2013-10-01
Sub-type Article (original research)
DOI 10.1093/gbe/evt145
Open Access Status DOI
Volume 5
Issue 10
Start page 1986
End page 1994
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
The chromosomal distribution of genes with sex-biased expression is often nonrandom, and in species with XY sex chromosome systems, it is common to observe a deficit of X-linked male-biased genes and an excess of X-linked female-biased genes. One explanation for this pattern is that sex-specific selection has shaped the gene content of the X. Alternatively, the deficit of male-biased and excess of female-biased genes could be an artifact of differences between the sexes in the global expression level of their X chromosome(s), perhaps brought about by a lack of dosage compensation in males and hyperexpression in females. In the montium fruit fly, Drosophila serrata, both these explanations can account for a deficit of male-biased and excess of female-biased X-linked genes. Using genome-wide expression data from multiple male and female tissues (n = 176 hybridizations), we found that testis- and accessory gland-specific genes are underrepresented whereas female ovary-specific genes are overrepresented on the X chromosome, suggesting that X-linkage is disfavored for male function genes but favored for female function genes. However, genes with such sex-specific functions did not fully account for the deficit of male-biased and excess of female-biased X-linked genes. We did, however, observe sex differences in the global expression level of the X chromosome and autosomes. Surprisingly, and in contrast to other species where a lack of dosage compensation in males is responsible, we found that hyperexpression of X-linked genes in both sexes leads to this imbalance in D. serrata. Our results highlight how common genomic distributions of sex-biased genes, even among closely related species, may arise via quite different evolutionary processes.
Keyword Sex-biased gene expression
X chromosome
Dosage compensation
Drosophila
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biological Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 22 Dec 2013, 10:16:09 EST by System User on behalf of School of Biological Sciences