Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts

Zabaneh, Delilah, Kumari, , Meena, Sandhu, Manj, Wareham, Nick, Wainwright, Nick, Papamarkou, Theodore, Hopewell, Jemma, Clarke, Robert, Li, KaWah, Palmen, Jutta, Talmud, Philippa J., Kronenberg, Florian, Lamina, Claudia, Summerer, Monika, Paulweber, Bernhard, Price, Jackie, Fowkes, Gerry, Stewart, Marlene, Drenos, Fotios, Shah, Sonia, Shah, Tina, Casas, Juan-Pablo, Kivimaki, Mika, Whittaker, John, Hingorani, Aroon D. and Humphries, Steve E. (2011) Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts. Atherosclerosis, 217 2: 447-451. doi:10.1016/j.atherosclerosis.2011.04.015


Author Zabaneh, Delilah
Kumari, , Meena
Sandhu, Manj
Wareham, Nick
Wainwright, Nick
Papamarkou, Theodore
Hopewell, Jemma
Clarke, Robert
Li, KaWah
Palmen, Jutta
Talmud, Philippa J.
Kronenberg, Florian
Lamina, Claudia
Summerer, Monika
Paulweber, Bernhard
Price, Jackie
Fowkes, Gerry
Stewart, Marlene
Drenos, Fotios
Shah, Sonia
Shah, Tina
Casas, Juan-Pablo
Kivimaki, Mika
Whittaker, John
Hingorani, Aroon D.
Humphries, Steve E.
Title Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
1879-1484
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.atherosclerosis.2011.04.015
Volume 217
Issue 2
Start page 447
End page 451
Total pages 5
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier Ireland Ltd
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Abstract Background: Both genome-wide association studies and candidate gene studies have reported that the major determinant of plasma levels of the Lipoprotein (a) [Lp(a)] reside within the LPA locus on chromosome 6. We have used data from the HumanCVD BeadChip to explore the contribution of other candidate genes determining Lp(a) levels. Methods: 48,032 single nucleotide polymorphisms (SNPs) from the Illumina HumanCVD BeadChip were genotyped in 5059 participants of the Whitehall II study (WHII) of randomly ascertained healthy men and women. SNPs showing association with Lp(a) levels of p<10 -4 outside the LPA locus were selected for replication in a total of an additional 9463 participants of five European based studies (EAS, EPIC-Norfolk, NPHSII, PROCARDIS, and SAPHIR). Results: In Whitehall II, apart from the LPA locus (where p values for several SNPs were <10 -30) there was significant association at four loci GALNT2, FABP1, PPARGC1A and TNFRSFF11A. However, a meta-analysis of the six studies did not confirm any of these findings. Conclusion: Results from this meta analysis of 14,522 participants revealed no candidate genes from the HumanCVD BeadChip outside the LPA locus to have an effect on Lp(a) levels. Further studies with genome-wide and denser SNP coverage are required to confirm or refute this finding.
Keyword Genetic association
Illumina HumanCVD BeadChip
Lipoprotein(a)
LPA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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