Behavioural and metabolic risk factors for mortality from colon and rectum cancer: analysis of data from the Asia-Pacific Cohort Studies collaboration

Morrison, David Stewart, Parr, Christine Louise, Lam, Tai Hing, Ueshima, Hirotsugu, Kim, Hyeon Chang, Jee, Sun Ha, Murakami, Yoshitaka, Giles, Graham, Fang, Xianghua, Barzi, Federica, Batty, George David, Huxley, Rachel Rita and Woodward, Mark (2013) Behavioural and metabolic risk factors for mortality from colon and rectum cancer: analysis of data from the Asia-Pacific Cohort Studies collaboration. Asian Pacific Journal of Cancer Prevention, 14 2: 1083-1087. doi:10.7314/APJCP.2013.14.2.1083

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Morrison, David Stewart
Parr, Christine Louise
Lam, Tai Hing
Ueshima, Hirotsugu
Kim, Hyeon Chang
Jee, Sun Ha
Murakami, Yoshitaka
Giles, Graham
Fang, Xianghua
Barzi, Federica
Batty, George David
Huxley, Rachel Rita
Woodward, Mark
Title Behavioural and metabolic risk factors for mortality from colon and rectum cancer: analysis of data from the Asia-Pacific Cohort Studies collaboration
Journal name Asian Pacific Journal of Cancer Prevention   Check publisher's open access policy
ISSN 1513-7368
Publication date 2013-01-01
Sub-type Article (original research)
DOI 10.7314/APJCP.2013.14.2.1083
Open Access Status Not Open Access
Volume 14
Issue 2
Start page 1083
End page 1087
Total pages 5
Place of publication Bangkok, Thailand
Publisher Asian Pacific Organization for Cancer Prevention
Language eng
Subject 2730 Oncology
1306 Cancer Research
2739 Public Health, Environmental and Occupational Health
2713 Epidemiology
Formatted abstract
Background: Colorectal cancer has several modifiable behavioural risk factors but their relationship to the risk of colon and rectum cancer separately and between countries with high and low incidence is not clear.

Methods: Data from participants in the Asia Pacific Cohort Studies Collaboration (APCSC) were used to estimate mortality from colon (International Classification of Diseases, revision 9 (ICD-9) 153, ICD-10 C18) and rectum (ICD-9 154, ICD-10 C19-20) cancers. Data on age, body mass index (BMI), serum cholesterol, height, smoking, physical activity, alcohol and diabetes mellitus were entered into Cox proportional hazards models.

Results: 600,427 adults contributed 4,281,239 person-years follow-up. The mean ages (SD) for Asian and Australia/New Zealand cohorts were 44.0 (9.5) and 53.4 (14.5) years, respectively. 455 colon and 158 rectum cancer deaths were observed. Increasing age, BMI and attained adult height were associated with increased hazards of death from colorectal cancer, and physical activity was associated with a reduced hazard. After multiple adjustment, any physical activity was associated with a 28% lower hazard of colon cancer mortality (HR 0.72, 95%CI 0.53-0.96) and lower rectum cancer mortality (HR 0.75, 95%CI 0.45-1.27). A 2cm increase in height increased colon and all colorectal cancer mortality by 7% and 6% respectively.

Conclusions: Physical inactivity and greater BMI are modifiable risk factors for colon cancer in both Western and Asian populations. Further efforts are needed to promote physical activity and reduce obesity while biological research is needed to understand the mechanisms by which they act to cause cancer mortality.
Keyword Anthropometric
Behavioural
Cancer
Colon
Mortality
Rectum
Risk factors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 21 Dec 2013, 05:02:38 EST by System User on behalf of School of Medicine