Functional alterations of large-scale brain networks related to cognitive control in obsessive-compulsive disorder

Cocchi, Luca, Harrison, Ben J., Pujol, Jesus, Harding, Ian H., Fornito, Alex, Pantelis, Christos and Yücel, Murat (2012) Functional alterations of large-scale brain networks related to cognitive control in obsessive-compulsive disorder. Human Brain Mapping, 33 5: 1089-1106. doi:10.1002/hbm.21270


Author Cocchi, Luca
Harrison, Ben J.
Pujol, Jesus
Harding, Ian H.
Fornito, Alex
Pantelis, Christos
Yücel, Murat
Title Functional alterations of large-scale brain networks related to cognitive control in obsessive-compulsive disorder
Journal name Human Brain Mapping   Check publisher's open access policy
ISSN 1065-9471
1097-0193
Publication date 2012-05-01
Year available 2011
Sub-type Article (original research)
DOI 10.1002/hbm.21270
Open Access Status Not Open Access
Volume 33
Issue 5
Start page 1089
End page 1106
Total pages 18
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Objectives: Neuroimaging studies have consistently implicated alterations of the basal ganglia and orbitofrontal cortex in the pathophysiology of OCD, however, recent work also emphasizes more diffuse patterns of brain alteration as occurring in this disorder. The goal of this study was to extend such observations by investigating large-scale brain functional network correlates of cognitive-control performance in OCD patients.

Experimental design: We combined fMRI with a validated task of cognitive control and a multivariate statistical method to assess multiple functional networks encompassing broad task-relevant cortical regions in OCD patients and matched controls. Functional networks of interest were targeted a priori and the groups were compared in terms of the spatiotemporal profile of network responses (functional connectivity) during the task performance in a data-driven manner.

Principal observations: Task performance was equivalent in both groups and each distinct network demonstrated strong overlap in its general response during task. However, significant differences in functional connectivity were also observed between groups that appeared driven by specific phases of task performance. Such differences were most pronounced during rest-task transitions and mainly involved dorsal anterior cingulate and insular cortices within the paralimbic network. Relative heightened functional connectivity of insula in patients during task correlated with a measure of patients' state anxiety.

Conclusions: Our findings provide a novel functional imaging characterization of brain network alterations associated with cognitive-control in OCD. Additionally, these findings raise questions about the role of patients' arousal states on the performance of cognitive imaging tasks that are otherwise assumed to be emotionally neutral.
Keyword Obsessive-compulsive disorder
fMRI
Functional connectivity
Arousal
Insular cortex
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID PBLAB3-119622
PASMP3_129357/1
628509509345
454797
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 17 Dec 2013, 22:00:48 EST by Luca Cocchi on behalf of Queensland Brain Institute