Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis

Naing, Cho, Whittaker, Maxine A., Nyunt-Wai, Victor, Reid, Simon A., Wong, Shew Fung, Mak, Joon Wah and Tanner, Marcel (2013) Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 107 11: 672-683. doi:10.1093/trstmh/trt086


Author Naing, Cho
Whittaker, Maxine A.
Nyunt-Wai, Victor
Reid, Simon A.
Wong, Shew Fung
Mak, Joon Wah
Tanner, Marcel
Title Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis
Journal name Transactions of the Royal Society of Tropical Medicine and Hygiene   Check publisher's open access policy
ISSN 0035-9203
1878-3503
Publication date 2013-11-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/trstmh/trt086
Volume 107
Issue 11
Start page 672
End page 683
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 2405 Parasitology
2725 Infectious Diseases
2739 Public Health, Environmental and Occupational Health
Abstract This study aimed to synthesize available evidence on the extent of malaria and soil-transmitted intestinal helminth (STH) co-infections in people living in endemic countries and to explore the effect of interactions between malaria and STHs on anemia. We searched relevant studies in electronic databases up to March 2013. Studies comparing malaria and STH co-infected patients with those not co-infected were included and the effect estimates were pooled using a random-effects model. We identified 30 studies for meta-analyses of which 17 were cross-sectional design. The majority of included studies (80%) were carried out in African countries. Among pregnant women, those infected with hookworm were found to have higher association with malaria infection compared with those without (summary OR: 1.36; 95% CI: 1.17-1.59; I2: 0%). Among nonpregnant adults, the summary OR of the association between anemia and the combined malaria and STH was 2.91 (1.38-6.14). The summary OR of the association between anemia and malaria alone was 1.53 (0.97-2.42), while the association between anemia and STH alone was 0.28 (0.04-1.95). There is no good evidence to support a different effect of malaria and STH on anemia. A subgroup analysis showed a higher risk of malaria infection in the primigravidae (summary OR: 1.61; 95% CI: 1.3-1.99; I2: 0%). In conclusion, the malaria-STH co-infection was variable with complex outcomes on anemia.
Keyword Anemia
Co-infection
Helminths
Malaria
Prevalence
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Public Health Publications
 
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