A randomized trial of dietary sodium restriction in CKD

McMahon, Emma J., Bauer, Judith D., Hawley, Carmel M., Isbel, Nicole M, Stowasser, Michael, Johnson, David W. and Campbell, Katrina L. (2013) A randomized trial of dietary sodium restriction in CKD. Journal of the American Society of Nephrology, 24 12: 2096-2103. doi:10.1681/ASN.2013030285

Author McMahon, Emma J.
Bauer, Judith D.
Hawley, Carmel M.
Isbel, Nicole M
Stowasser, Michael
Johnson, David W.
Campbell, Katrina L.
Title A randomized trial of dietary sodium restriction in CKD
Journal name Journal of the American Society of Nephrology   Check publisher's open access policy
ISSN 1046-6673
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1681/ASN.2013030285
Open Access Status Not yet assessed
Volume 24
Issue 12
Start page 2096
End page 2103
Total pages 8
Place of publication Washington, DC United States
Publisher American Society of Nephrology
Language eng
Subject 2727 Nephrology
Abstract There is a paucity of quality evidence regarding the effects of sodium restriction in patients with CKD, particularly in patients with pre-end stage CKD, where controlling modifiable risk factors may be especially important for delaying CKD progression and cardiovascular events. We conducted a doubleblind placebo-controlled randomized crossover trial assessing the effects of high versus low sodium intake on ambulatory BP, 24-hour protein and albumin excretion, fluid status (body compositionmonitor), renin and aldosterone levels, and arterial stiffness (pulse wave velocity and augmentation index) in 20 adult patients with hypertensive stage 3-4 CKD as phase 1 of the LowSALT CKD study. Overall, salt restriction resulted in statistically significant and clinically important reductions in BP (mean reduction of systolic/diastolic BP, 10/4 mm Hg; 95% confidence interval, 5 to 15 /1 to 6 mm Hg), extracellular fluid volume, albuminuria, and proteinuria in patientswithmoderate-to-severe CKD. The magnitude of change was more pronounced than the magnitude reported in patients without CKD, suggesting that patients withCKDare particularly salt sensitive. Although studieswith longer intervention times and larger sample sizes are needed to confirm these benefits, this study indicates that sodium restriction should be emphasized in the management of patients with CKD as a means to reduce cardiovascular risk and risk for CKD progression. Copyright
Keyword Cardiovascualr disease
CKD patients
Sodium Restriction
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 86 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 88 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 17 Dec 2013, 10:20:20 EST by System User on behalf of School of Human Movement and Nutrition Sciences