Cerebral blood flow is not affected during perfluorocarbon dosing with volume-controlled ventilation

Davies, Mark W., Dunster, Kimble R., Fraser, John F. and Colditz, Paul B. (2013) Cerebral blood flow is not affected during perfluorocarbon dosing with volume-controlled ventilation. Journal of Paediatrics and Child Health, 49 12: 1010-1018. doi:10.1111/jpc.12297

Author Davies, Mark W.
Dunster, Kimble R.
Fraser, John F.
Colditz, Paul B.
Title Cerebral blood flow is not affected during perfluorocarbon dosing with volume-controlled ventilation
Journal name Journal of Paediatrics and Child Health   Check publisher's open access policy
ISSN 1034-4810
Publication date 2013-12-01
Sub-type Article (original research)
DOI 10.1111/jpc.12297
Open Access Status Not Open Access
Volume 49
Issue 12
Start page 1010
End page 1018
Total pages 9
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Aims Perfluorocarbon administration increases cerebral blood flow. This can be mitigated by preventing a rise in carbon dioxide by adjusting pressure-controlled ventilation. Volume-controlled ventilation should prevent increases in arterial carbon dioxide and cerebral blood flow. This study aims to determine if cerebral blood flow is increased during administration of 10 mL/kg of perfluorocarbon while using volume-controlled ventilation.

Methods Two New Zealand white rabbits, ventilated with volume-control, were each allocated to six dosing events where each dosing event was randomly allocated to one of two dosing strategies: a control group – given a sham dose of air (10 mL/kg) over 20 min; or a partial liquid ventilation group – given 10 mL/kg FC-77 slowly over 20 min. Data were recorded for 1 min before and 30 min after the start of each dosing event. No adjustment of ventilation (except fraction of inspired oxygen) was allowed during each dosing event.

Results There were no significant changes over time and no differences between groups for carotid blood flow (P = 0.48 at the end of the dose). There were slight increases in cortical cerebral blood flow in both groups; there was no statistically significant difference between groups (P = 0.56 at end dose and P = 0.49 at time of maximum difference). There was no difference between groups for the variability in carotid blood flow or cortical cerebral blood flow.

Conclusions Cerebral blood flow was not significantly increased during administration of a dose of 10 mL/kg of perfluorocarbon during commencement of partial liquid ventilation when using volume-controlled ventilation.
Keyword Cerebral blood flow
Partial liquid ventilation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
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Created: Mon, 16 Dec 2013, 19:43:14 EST by Roheen Gill on behalf of Paediatrics & Child Health - RBWH