Magnetic resonance diffusion tractography of the preterm infant brain: a systematic review

Pannek, Kerstin, Scheck, Simon M., Colditz, Paul B., Boyd, Roslyn N. and Rose, Stephen E. (2014) Magnetic resonance diffusion tractography of the preterm infant brain: a systematic review. Developmental Medicine and Child Neurology, 56 2: 113-124. doi:10.1111/dmcn.12250

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Author Pannek, Kerstin
Scheck, Simon M.
Colditz, Paul B.
Boyd, Roslyn N.
Rose, Stephen E.
Title Magnetic resonance diffusion tractography of the preterm infant brain: a systematic review
Journal name Developmental Medicine and Child Neurology   Check publisher's open access policy
ISSN 0012-1622
1469-8749
Publication date 2014-02-01
Year available 2013
Sub-type Article (original research)
DOI 10.1111/dmcn.12250
Open Access Status Not yet assessed
Volume 56
Issue 2
Start page 113
End page 124
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract AimPreterm birth is associated with an increased risk of adverse neurodevelopmental outcomes. Diffusion magnetic resonance imaging (dMRI) combined with tractography can be used to assess non-invasively white matter microstructure and brain development in preterm infants. Our aim was to conduct a systematic review of the current evidence obtained from tractography studies of preterm infants in whom MRI was performed up to term-equivalent age.
Formatted abstract
Aim: Preterm birth is associated with an increased risk of adverse neurodevelopmental outcomes. Diffusion magnetic resonance imaging (dMRI) combined with tractography can be used to assess non-invasively white matter microstructure and brain development in preterm infants. Our aim was to conduct a systematic review of the current evidence obtained from tractography studies of preterm infants in whom MRI was performed up to term-equivalent age.

Method: Databases were searched for dMRI tractography studies of preterm infants.

Results: Twenty-two studies were assessed. The most frequently assessed tracts included the corticospinal tract, the corpus callosum, and the optic radiations. The superior longitudinal fasciculus, and the anterior and superior thalamic radiations were investigated less frequently. A clear relationship exists between diffusion metrics and postmenstrual age at the time of scanning, although the evidence of an effect of gestational age at birth and white matter injury is conflicting. Sex and laterality may play an important role in the relationship between diffusion metrics, early clinical assessment, and outcomes.

Interpretation: Studies involving infants of all gestational ages are required to elucidate the relationship between gestational age and diffusion metrics, and to establish the utility of tractography as a predictive tool. There is a need for more robust acquisition and analysis methods to improve the accuracy of assessing development of white matter pathways.
Keyword Clinical Neurology
Pediatrics
Neurosciences & Neurology
Pediatrics
CLINICAL NEUROLOGY
PEDIATRICS
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 10037220
Institutional Status UQ
Additional Notes Article first published online: 16 September 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Mon, 16 Dec 2013, 19:18:54 EST by Roheen Gill on behalf of School of Medicine