Exhaled breath analysis for lung cancer

Dent, Annette G., Sutedja, Tom G. and Zimmerman, Paul V. (2013) Exhaled breath analysis for lung cancer. Journal of Thoracic Disease, 5 SUPPL.5: S540-S550. doi:10.3978/j.issn.2072-1439.2013.08.44

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Author Dent, Annette G.
Sutedja, Tom G.
Zimmerman, Paul V.
Title Exhaled breath analysis for lung cancer
Journal name Journal of Thoracic Disease   Check publisher's open access policy
ISSN 2072-1439
Publication date 2013-10-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3978/j.issn.2072-1439.2013.08.44
Open Access Status Not yet assessed
Volume 5
Issue SUPPL.5
Start page S540
End page S550
Total pages 11
Place of publication Hong Kong, Hong Kong
Publisher Pioneer Bioscience Publishing Company
Language eng
Abstract Early diagnosis of lung cancer results in improved survival compared to diagnosis with more advanced disease. Early disease is not reliably indicated by symptoms. Because investigations such as bronchoscopy and needle biopsy have associated risks and substantial costs, they are not suitable for population screening. Hence new easily applicable tests, which can be used to screen individuals at risk, are required. Biomarker testing in exhaled breath samples is a simple, relatively inexpensive, non-invasive approach. Exhaled breath contains volatile and non-volatile organic compounds produced as end-products of metabolic processes and the composition of such compounds varies between healthy subjects and subjects with lung cancer. Many studies have analysed the patterns of these compounds in exhaled breath. In addition studies have also reported that the exhaled breath condensate (EBC) can reveal gene mutations or DNA abnormalities in patients with lung cancer. This review has summarised the scientific evidence demonstrating that lung cancer has distinct chemical profiles in exhaled breath and characteristic genetic changes in EBC. It is not yet possible to accurately identify individuals with lung cancer in at risk populations by any of these techniques. However, analysis of both volatile organic compounds in exhaled breath and of EBC have great potential to become clinically useful diagnostic and screening tools for early stage lung cancer detection.
Keyword Lung cancer
volatile organic compounds
exhaled breath
Volatile Organic-Compounds
Colorimetric Sensor Array
Canine Scent Detection
Olfactory Detection
Electronic Nose
Microsatellite Alterations
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: School of Medicine Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 42 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 42 times in Scopus Article | Citations
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