An emerging place for lung cancer genomics in 2013

Daniels, Marissa G., Bowman, Rayleen V., Yang, Ian A., Govindan, Ramaswamy and Fong, Kwun M. (2013) An emerging place for lung cancer genomics in 2013. Journal of Thoracic Disease, 5 SUPPL.5: S491-S497. doi:10.3978/j.issn.2072-1439.2013.10.06

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Author Daniels, Marissa G.
Bowman, Rayleen V.
Yang, Ian A.
Govindan, Ramaswamy
Fong, Kwun M.
Title An emerging place for lung cancer genomics in 2013
Journal name Journal of Thoracic Disease   Check publisher's open access policy
ISSN 2072-1439
Publication date 2013-10-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3978/j.issn.2072-1439.2013.10.06
Open Access Status Not yet assessed
Volume 5
Issue SUPPL.5
Start page S491
End page S497
Total pages 7
Place of publication Hong Kong, Hong Kong
Publisher Pioneer Bioscience Publishing Company
Language eng
Abstract Lung cancer is a disease with a dismal prognosis and is the biggest cause of cancer deaths in many countries. Nonetheless, rapid technological developments in genome science promise more effective prevention and treatment strategies. Since the Human Genome Project, scientific advances have revolutionized the diagnosis and treatment of human cancers, including thoracic cancers. The latest, massively parallel, next generation sequencing (NGS) technologies offer much greater sequencing capacity than traditional, capillary-based Sanger sequencing. These modern but costly technologies have been applied to whole genome-, and whole exome sequencing (WGS and WES) for the discovery of mutations and polymorphisms, transcriptome sequencing for quantification of gene expression, small ribonucleic acid (RNA) sequencing for microRNA profiling, large scale analysis of deoxyribonucleic acid (DNA) methylation and chromatin immunoprecipitation mapping of DNA-protein interaction.
Keyword High-throughput nucleotide sequencing
lung neoplasms
non-small cell lung carcinoma (NSCLC)
small cell lung carcinoma (SCLC)
Myeloid-Leukemia Genome
Somatic Mutations
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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