Association and expression analysis of porcine HNF1A gene related to meat and carcass quality traits

Kayan, Autchara, Uddin, Muhammad Jasim, Kocamis, Hakan, Tesfaye, Dawit, Looft, Christian, Tholen, Ernst, Schellander, Karl and Cinar, Mehmet Ulas (2013) Association and expression analysis of porcine HNF1A gene related to meat and carcass quality traits. Meat Science, 94 4: 474-479. doi:10.1016/j.meatsci.2013.04.015


Author Kayan, Autchara
Uddin, Muhammad Jasim
Kocamis, Hakan
Tesfaye, Dawit
Looft, Christian
Tholen, Ernst
Schellander, Karl
Cinar, Mehmet Ulas
Title Association and expression analysis of porcine HNF1A gene related to meat and carcass quality traits
Journal name Meat Science   Check publisher's open access policy
ISSN 0309-1740
1873-4138
Publication date 2013-08-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.meatsci.2013.04.015
Open Access Status
Volume 94
Issue 4
Start page 474
End page 479
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract The aim of this study was to investigate the association and expression of HNF1A gene as a candidate gene for meat and carcass quality traits in pigs. Statistical analysis revealed that the g.8260 A>G polymorphism significantly associated with pH24H, meat percentage and muscle area in the F2 Duroc×Pietrain (DuPi, n=313) and with pH24L, fat area and backfat thickness in the Pietrain (Pi, n=110) population. HNF1A mRNA and protein expressions were higher (p<0.05) in animals with the low post-mortem muscle pH24L. The promoter methylation profiling suggested that methylation was not involved on HNF1A expression regulation (p>0.05) in animal with divergent muscle pH. In conclusion, polymorphism in porcine HNF1A gene could be used as a candidate marker to improve the meat and carcass quality traits, with the consideration of breed-specific effect.
Keyword HNF1A
Single nucleotide polymorphism
mRNA and protein expression
Methylation
Meat quality
Pig
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID FOR 753
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Veterinary Science Publications
 
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