Thrombus volume is similar in patients with ruptured and intact abdominal aortic aneurysms

Golledge, Jonathan, Iyer, Vikram, Jenkins, Julie, Bradshaw, Barbara, Cronin, Oliver and Walker, Philip J. (2013) Thrombus volume is similar in patients with ruptured and intact abdominal aortic aneurysms. Journal of Vascular Surgery, 59 2: 315-320. doi:10.1016/j.jvs.2013.08.036


Author Golledge, Jonathan
Iyer, Vikram
Jenkins, Julie
Bradshaw, Barbara
Cronin, Oliver
Walker, Philip J.
Title Thrombus volume is similar in patients with ruptured and intact abdominal aortic aneurysms
Journal name Journal of Vascular Surgery   Check publisher's open access policy
ISSN 0741-5214
1097-6809
Publication date 2013-10-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.jvs.2013.08.036
Volume 59
Issue 2
Start page 315
End page 320
Total pages 6
Place of publication Philadelphia, United States
Publisher Mosby
Language eng
Formatted abstract
Objective: Most abdominal aortic aneurysms (AAAs) contain intraluminal thrombus (ILT), which has been demonstrated to contain proteolytic enzymes and proinflammatory cytokines implicated in AAA progression and rupture. In animal models, anticoagulants have been shown to limit AAA progression. Whether ILT plays a role in AAA rupture is unknown.

The aim of this study was to compare the volume of ILT in patients with ruptured and intact AAAs.

Methods: We matched by maximum axial diameter alone, on a 1:2 basis, 28 patients with ruptured AAAs and 56 patients with intact AAAs. Total infrarenal aortic volume and ILT volume were measured from computed tomography angiograms using a previously validated and reproducible semiautomated workstation protocol. Clinical risk factors were also recorded. The Mann-Whitney U test was used to compare ILT volumes between patients with ruptured and intact AAAs.

Results: Median (interquartile range [IQR]) maximum AAA diameter (84.0 [77.5-93.9] mm vs 82.6 [77.1-93.3] mm; P[ .769) and median (IQR) total AAA volume (372.8 [277.4-486.1] cm3 vs 358.4 [289.1-563.4] cm3; P [ .977) were similar in patients with ruptured and intact AAAs. Median (IQR) AAA ILT volume was similar in patients with ruptured (152.7 [84.8-252.4] cm3) and intact (180.1 [89.9-254.8] cm3; P [ .414) AAAs.

Conclusions: This study suggests that ILT volume is not different in ruptured and intact AAAs.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 10 October 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 11 Dec 2013, 22:02:59 EST by Roheen Gill on behalf of UQ Centre for Clinical Research