The association of visceral adiposity with cardiovascular events in patients with peripheral artery disease

Cronin, Oliver, Bradshaw, Barbara, Iyer, Vikram, Cunningham, Margaret, Buttner, Petra, Walker, Philip J. and Golledge, Jonathan (2013) The association of visceral adiposity with cardiovascular events in patients with peripheral artery disease. PloS One, 8 12: e82350.1-e82350.8. doi:10.1371/journal.pone.0082350


Author Cronin, Oliver
Bradshaw, Barbara
Iyer, Vikram
Cunningham, Margaret
Buttner, Petra
Walker, Philip J.
Golledge, Jonathan
Title The association of visceral adiposity with cardiovascular events in patients with peripheral artery disease
Journal name PloS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0082350
Open Access Status DOI
Volume 8
Issue 12
Start page e82350.1
End page e82350.8
Total pages 9
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Formatted abstract
Background: Previous studies have suggested that patients with peripheral artery disease (PAD) suffer from a high
incidence of cardiovascular events (CVE). Visceral adiposity has been implicated in promoting CVEs. This study aimed to
assess the association of relative visceral adipose volume with incident cardiovascular events in patients with peripheral
artery disease.

Methods: This was a prospective cohort study including 260 patients with PAD who presented between 2003 and 2012.
Cases were patients with diagnosed PAD including symptomatic lower limb athero-thrombosis and asymptomatic
abdominal aortic aneurysm. All patients underwent computed tomography angiography (CTA). Abdominal visceral to total
adipose volume ratio (relative visceral adipose volume) was estimated from CTAs using a previously validated workstation
protocol. Cardiovascular risk factors were recorded at entry. The association of visceral adiposity with major CVEs (death,
non-fatal myocardial infarction or stroke) was examined using Kaplan Meier and Cox proportional hazard analyses.

Results
: A total of 92 major CVEs were recorded in 76 patients during a median follow-up of 2.8 (IQR 1.2 to 4.8) years,
including myocardial infarction (n = 26), stroke (n = 10) and death (n = 56). At 3 years the incidence of major CVEs stratified
by relative visceral adipose volume quartiles were 15% [Quartile (Q) 1], 17% (Q2), 11% (Q3) and 15% (Q4) (P = 0.517). Relative
visceral adipose volume was not associated with major CVEs after adjustment for other risk factors.

Conclusion:
This study suggests that visceral adiposity does not play a central role in the predisposition for major CVEs in
patients with PAD.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
 
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Created: Wed, 11 Dec 2013, 21:35:19 EST by Roheen Gill on behalf of UQ Centre for Clinical Research