Association of chronic kidney disease categories defined with different formulae with major adverse events in patients with peripheral vascular disease

Golledge, Jonathan, Ewels, Carla, Muller, Reinhold and Walker, Philip J. (2013) Association of chronic kidney disease categories defined with different formulae with major adverse events in patients with peripheral vascular disease. Atherosclerosis, 232 2: 289-297. doi:10.1016/j.atherosclerosis.2013.11.034


Author Golledge, Jonathan
Ewels, Carla
Muller, Reinhold
Walker, Philip J.
Title Association of chronic kidney disease categories defined with different formulae with major adverse events in patients with peripheral vascular disease
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
1879-1484
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.atherosclerosis.2013.11.034
Open Access Status
Volume 232
Issue 2
Start page 289
End page 297
Total pages 19
Place of publication Clare, Ireland
Publisher Elsevier
Language eng
Formatted abstract
Objective: The aim of this study was to compare the ability of eGFR calculated by modification of diet in renal disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Lund-Malmö formulae in predicting major adverse events in peripheral vascular disease (PVD) patients.

Methods: We prospectively recruited 2137 patients, measured serum creatinine to calculate eGFR using three different formulae and grouped patients into eGFR categories ≥90, 60-89, 45-59, 30-44, 15-29 and <15 ml/min/1.73m2. Patients were followed up for a median of 1.3 (inter-quartile range 0.3-3.6) years. The primary outcome was the combined incidence of myocardial infarction, stroke or death. The ability of eGFR categories defined with the different formulae to predict outcome was assessed using the net reclassification index.

Results: 1450 (67.9%), 1515 (70.9%) and 1813 (84.8%) patients had eGFR <90 ml/min/1.73m2 according to the CKD-EPI, MDRD and Lund-Malmö formulae, respectively. Using the CKD-EPI formula 276 (12.9%) patients were reclassified to a different eGFR category in comparison to the MDRD formula and the prediction of outcome was improved (net reclassification index 0.106, p<0.001). Using the Lund-Malmö formula 563 (26.3%) patients were reclassified to a different eGFR category in comparison to the MDRD formula and the prediction of outcome was improved (net reclassification index 0.108, p<0.001). Classification using the CKD-EPI and Lund-Malmö formulae was equally effective at predicting outcome (net reclassification index - 0.002, p=0.397).

Conclusions: eGFR categories determined with the CKD-EPI and Lund-Malmö formulae are equally effective at predicting major adverse events in patients with PVD.
Keyword Peripheral vascular disease
Chronic kidney disease
Estimated glomerular filtration rate
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 2 December 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
 
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Created: Wed, 11 Dec 2013, 21:28:14 EST by Roheen Gill on behalf of UQ Centre for Clinical Research