Patterns in space: coordinating adhesion and actomyosin contractility at E-cadherin junctions

Wu, Selwin Kaixiang and Yap, Alpha S. (2013) Patterns in space: coordinating adhesion and actomyosin contractility at E-cadherin junctions. Cell Communication and Adhesion, 20 6: 201-212. doi:10.3109/15419061.2013.856889


Author Wu, Selwin Kaixiang
Yap, Alpha S.
Title Patterns in space: coordinating adhesion and actomyosin contractility at E-cadherin junctions
Journal name Cell Communication and Adhesion   Check publisher's open access policy
ISSN 1541-9061
1543-5180
1026-7883
Publication date 2013-12-01
Year available 2015
Sub-type Article (original research)
DOI 10.3109/15419061.2013.856889
Open Access Status
Volume 20
Issue 6
Start page 201
End page 212
Total pages 12
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Abstract Cadherin adhesion receptors are fundamental determinants of tissue organization in health and disease. Increasingly, we have come to appreciate that classical cadherins exert their biological actions through active cooperation with the contractile actin cytoskeleton. Rather than being passive resistors of detachment forces, cadherins can regulate the assembly and mechanics of the contractile apparatus itself. Moreover, coordinate spatial patterning of adhesion and contractility is emerging as a determinant of morphogenesis. Here we review recent developments in cadherins and actin cytoskeleton cooperativity, by focusing on E-cadherin adhesive patterning in the epithelia. Next, we discuss the underlying principles of cellular rearrangement during Drosophila germband extension and epithelial cell extrusion, as models of how planar and apical-lateral patterns of contractility organize tissue architecture.
Formatted abstract
Cadherin adhesion receptors are fundamental determinants of tissue organization in health and disease. Increasingly, we have come to appreciate that classical cadherins exert their biological actions through active cooperation with the contractile actin cytoskeleton. Rather than being passive resistors of detachment forces, cadherins can regulate the assembly and mechanics of the contractile apparatus itself. Moreover, coordinate spatial patterning of adhesion and contractility is emerging as a determinant of morphogenesis. Here we review recent developments in cadherins and actin cytoskeleton cooperativity, by focusing on E-cadherin adhesive patterning in the epithelia. Next, we discuss the underlying principles of cellular rearrangement during Drosophila germband extension and epithelial cell extrusion, as models of how planar and apical–lateral patterns of contractility organize tissue architecture.
Keyword E-cadherin
Contractility
Actomyosin
Morphogenesis
Cell extrusion
Tension
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 63183
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Wed, 11 Dec 2013, 00:37:55 EST by Susan Allen on behalf of Institute for Molecular Bioscience