Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group

Gottardo, Nicholas G., Hansford, Jordan R., McGlade, Jacqueline P., Alvaro, Frank, Ashley, David M., Bailey, Simon, Baker, David L., Bourdeaut, Franck, Cho, Yoon‑Jae, Clay, Moira, Clifford, Steven C., Cohn, Richard J., Cole, Catherine H., Dallas, Peter B., Downie, Peter, Doz, François, Ellison, David W., Endersby, Raelene, Fisher, Paul G., Hassall, Timothy, Heath, John A., Hii, Hilary L., Jones, David T. W., Junckerstorff, Reimar, Kellie, Stewart, Kool, Marcel, Kotecha, Rishi S., Lichter, Peter, Laughton, Stephen J., Lee, Sharon, McCowage, Geoff, Northcott, Paul A., Olson, James M., Packer, Roger J., Pfister, Stefan M., Pietsch, Torsten, Pizer, Barry, Pomeroy, Scott L., Remke, Marc, Robinson, Giles W., Rutkowski, Stefan, Schoep, Tobias, Shelat, Anang A., Stewart, Clinton F., Sullivan, Michael, Taylor, Michael D., Wainwright, Brandon, Walwyn, Thomas, Weiss, William A., Williamson, Dan and Gajjar, Amar (2013) Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group. Acta Neuropathologica, 127 2: 189-201. doi:10.1007/s00401-013-1213-7

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Author Gottardo, Nicholas G.
Hansford, Jordan R.
McGlade, Jacqueline P.
Alvaro, Frank
Ashley, David M.
Bailey, Simon
Baker, David L.
Bourdeaut, Franck
Cho, Yoon‑Jae
Clay, Moira
Clifford, Steven C.
Cohn, Richard J.
Cole, Catherine H.
Dallas, Peter B.
Downie, Peter
Doz, François
Ellison, David W.
Endersby, Raelene
Fisher, Paul G.
Hassall, Timothy
Heath, John A.
Hii, Hilary L.
Jones, David T. W.
Junckerstorff, Reimar
Kellie, Stewart
Kool, Marcel
Kotecha, Rishi S.
Lichter, Peter
Laughton, Stephen J.
Lee, Sharon
McCowage, Geoff
Northcott, Paul A.
Olson, James M.
Packer, Roger J.
Pfister, Stefan M.
Pietsch, Torsten
Pizer, Barry
Pomeroy, Scott L.
Remke, Marc
Robinson, Giles W.
Rutkowski, Stefan
Schoep, Tobias
Shelat, Anang A.
Stewart, Clinton F.
Sullivan, Michael
Taylor, Michael D.
Wainwright, Brandon
Walwyn, Thomas
Weiss, William A.
Williamson, Dan
Gajjar, Amar
Title Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group
Journal name Acta Neuropathologica   Check publisher's open access policy
ISSN 0001-6322
Publication date 2013-11-22
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00401-013-1213-7
Open Access Status DOI
Volume 127
Issue 2
Start page 189
End page 201
Total pages 13
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in improving survival using conventional therapies has stalled, resulting in reduced quality of life due to treatment-related side effects, which are a major concern in survivors. The vast amount of genomic and molecular data generated over the last 5–10 years encourages optimism that improved risk stratification and new molecular targets will improve outcomes. It is now clear that medulloblastoma is not a single-disease entity, but instead consists of at least four distinct molecular subgroups: WNT/Wingless, Sonic Hedgehog, Group 3, and Group 4. The Medulloblastoma Down Under 2013 meeting, which convened at Bunker Bay, Australia, brought together 50 leading clinicians and scientists. The 2-day agenda included focused sessions on pathology and molecular stratification, genomics and mouse models, high-throughput drug screening, and clinical trial design. The meeting established a global action plan to translate novel biologic insights and drug targeting into treatment regimens to improve outcomes. A consensus was reached in several key areas, with the most important being that a novel classification scheme for medulloblastoma based on the four molecular subgroups, as well as histopathologic features, should be presented for consideration in the upcoming fifth edition of the World Health Organization’s classification of tumours of the central nervous system. Three other notable areas of agreement were as follows: (1) to establish a central repository of annotated mouse models that are readily accessible and freely available to the international research community; (2) to institute common eligibility criteria between the Children’s Oncology Group and the International Society of Paediatric Oncology Europe and initiate joint or parallel clinical trials; (3) to share preliminary high-throughput screening data across discovery labs to hasten the development of novel therapeutics. Medulloblastoma Down Under 2013 was an effective forum for meaningful discussion, which resulted in enhancing international collaborative clinical and translational research of this rare disease. This template could be applied to other fields to devise global action plans addressing all aspects of a disease, from improved disease classification, treatment stratification, and drug targeting to superior treatment regimens to be assessed in cooperative international clinical trials.

The third annual meeting of the International Medulloblastoma Working Group took place at Bunker Bay, Western Australia, February 12–13, 2013. Fifty leading researchers and clinicians from Australia, Canada, France, Germany, New Zealand, the United Kingdom, and the United States of America came together to discuss their most recent findings and create an international plan of action for medulloblastoma research. The group’s focus was on integrating novel biological insights gained from preclinical models and high-throughput drug screening (HTS) into the next generation of clinical trials.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 22 November 2013

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 35 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 44 times in Scopus Article | Citations
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Created: Tue, 10 Dec 2013, 22:14:17 EST by Susan Allen on behalf of Institute for Molecular Bioscience