Peptide conjugation via CuAAC 'click' chemistry

Ahmad Fuaad, Abdullah A. H., Azmi, Fazren, Skwarczynski, Mariusz and Toth, Istvan (2013) Peptide conjugation via CuAAC 'click' chemistry. Molecules, 18 11: 13148-13174. doi:10.3390/molecules181113148

Author Ahmad Fuaad, Abdullah A. H.
Azmi, Fazren
Skwarczynski, Mariusz
Toth, Istvan
Title Peptide conjugation via CuAAC 'click' chemistry
Journal name Molecules   Check publisher's open access policy
ISSN 1420-3049
Publication date 2013-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/molecules181113148
Open Access Status DOI
Volume 18
Issue 11
Start page 13148
End page 13174
Total pages 27
Place of publication Basel, Switzerland
Publisher M D P I AG
Language eng
Subject 1605 Policy and Administration
Abstract The copper (I)-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) or 'click' reaction, is a highly versatile reaction that can be performed under a variety of reaction conditions including various solvents, a wide pH and temperature range, and using different copper sources, with or without additional ligands or reducing agents. This reaction is highly selective and can be performed in the presence of other functional moieties. The flexibility and selectivity has resulted in growing interest in the application of CuAAC in various fields. In this review, we briefly describe the importance of the structural folding of peptides and proteins and how the 1,4-disubstituted triazole product of the CuAAC reaction is a suitable isoster for an amide bond. However the major focus of the review is the application of this reaction to produce peptide conjugates for tagging and targeting purpose, linkers for multifunctional biomacromolecules, and reporter ions for peptide and protein analysis.
Keyword Chemical ligation
Click chemistry
Peptide ligation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
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