Personalizing and targeting therapy for COPD - The role of molecular and clinical biomarkers

Goh, Felicia, Shaw, Janet G., Francis. Santiyagu M. Savarimuthu, Vaughan, Annalicia, Morrison, Leanne, Relan, Vandana, Marshall, Henry M., Dent, Annette G., O'Hare, Phoebe E., Hsiao, Amy, Bowman, Rayleen V., Fong, Kwun M. and Yang, Ian A. (2013) Personalizing and targeting therapy for COPD - The role of molecular and clinical biomarkers. Expert Review of Respiratory Medicine, 7 6: 593-605. doi:10.1586/17476348.2013.842468


Author Goh, Felicia
Shaw, Janet G.
Francis. Santiyagu M. Savarimuthu
Vaughan, Annalicia
Morrison, Leanne
Relan, Vandana
Marshall, Henry M.
Dent, Annette G.
O'Hare, Phoebe E.
Hsiao, Amy
Bowman, Rayleen V.
Fong, Kwun M.
Yang, Ian A.
Title Personalizing and targeting therapy for COPD - The role of molecular and clinical biomarkers
Journal name Expert Review of Respiratory Medicine   Check publisher's open access policy
ISSN 1747-6348
1747-6356
Publication date 2013-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1586/17476348.2013.842468
Volume 7
Issue 6
Start page 593
End page 605
Total pages 13
Place of publication London, United Kingdom
Publisher Expert Reviews Ltd
Language eng
Subject 2740 Pulmonary and Respiratory Medicine
2723 Immunology and Allergy
2739 Public Health, Environmental and Occupational Health
Abstract Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by persistent airflow limitation. It is the third leading cause of death worldwide, and there are currently no curative strategies for this disease. Many factors contribute to COPD susceptibility, progression and exacerbations. These include cigarette smoking, environmental and occupational pollutants, respiratory infections and comorbidities. As the clinical phenotypes of COPD are so variable, it has been difficult to devise an individualized treatment plan for patients with this complex chronic disease. This review will highlight how potential clinical, inflammatory, genomic and epigenomic biomarkers for COPD could be used to personalize treatment, leading to improved disease management and prevention for our patients.
Keyword Biomarkers
Chronic obstructive pulmonary disease
Clinical
Diagnosis
Genomic
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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