Association between ultraviolet radiation, skin sun sensitivity and risk of pancreatic cancer

Tran, Bich, Whiteman, David C., Webb, Penelope M., Fritschi, Lin, Fawcett, Jonathan, Risch, Harvey A., Lucas, Robyn, Pandeya, Nirmala, Schulte, Annaka and Neale, Rachel E. (2013) Association between ultraviolet radiation, skin sun sensitivity and risk of pancreatic cancer. Cancer Epidemiology, 37 6: 886-892. doi:10.1016/j.canep.2013.08.013

Author Tran, Bich
Whiteman, David C.
Webb, Penelope M.
Fritschi, Lin
Fawcett, Jonathan
Risch, Harvey A.
Lucas, Robyn
Pandeya, Nirmala
Schulte, Annaka
Neale, Rachel E.
Title Association between ultraviolet radiation, skin sun sensitivity and risk of pancreatic cancer
Journal name Cancer Epidemiology   Check publisher's open access policy
ISSN 1877-7821
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.canep.2013.08.013
Open Access Status
Volume 37
Issue 6
Start page 886
End page 892
Total pages 7
Place of publication New York, NY United States
Publisher Elsevier Inc.
Language eng
Subject 1306 Cancer Research
2730 Oncology
2713 Epidemiology
Abstract Background: Ecological studies showing an inverse association between pancreatic cancer incidence and mortality and levels of ultraviolet radiation (UVR), suggest that higher levels of sun exposure may reduce risks of pancreatic cancer but there has been only one individual-level study that examined this issue. We aimed to examine the association between pancreatic cancer and markers of exposure to solar UVR, namely skin type, treatment of skin lesions, ambient UVR and time outdoors on work days. Methods: We used data from an Australian case-control study. Location at birth, residential location during adulthood, outdoors work, history of skin lesion treatment and sensitivity of the skin to the sun were obtained by questionnaire. We limited the analyses to Caucasians who answered the questionnaire about UVR (controls = 589/711 recruited; cases = 496/705 recruited). We used NASA's Total Ozone Mapping Spectrometer to estimate ambient UVR. Results: Being born in or living in areas of higher ambient UVR (compared to lower ambient UVR) was associated with about 30-40% lower risk of pancreatic cancer. People with fair skin colour had 47% lower risk of pancreatic cancer than those with dark skin colour (95% CI 0.37-0.75). There was some suggestion of increased risk with increased average number of hours spent outside at work. Conclusions: This study suggests that people with light skin colour or those born or living in areas of high ambient UVR have lower risk of pancreatic cancer. Our analysis supports an association between UVR and pancreatic cancer, possibly mediated through production of vitamin D.
Keyword History of skin cancer
Pancreatic cancer
Skin colour
Skin type
Ultraviolet radiation
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 442302
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
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